Ergogenic Aids: Vanadyl Sulfate - Mind And Muscle

muscled guy curlingVanadyl sulfate is a form of the trace mineral vanadium. Vanadyl is typically used for its ability to exert insulin-like effects, which is useful in treating high blood glucose levels and in increasing glycogen storage in skeletal muscle tissue.

Vanadyl sulfate has the ability to lower blood glucose levels. Research suggests that this effect of vanadyl sulfate is due to its ability to increase insulin sensitivity in skeletal muscle and liver tissue, which can be beneficial for anyone looking to improve their body composition. Unfortunately, vanadyl sulfate has been found to not work nearly as well in non-diabetic patients as in those with type 2 diabetes. There are probably better options available to improve glycogen synthesis and decrease the storage of carbohydrates as fat, but still it may be a solid addition to a nutrient partitioning supplement along with other ingredients.

Like many other insulin mimickers, when over-consumed vanadyl sulfate may cause a state of hypoglycemia. Anyone beginning use of vanadyl sulfate should start at a low dose, and increase steadily to find the proper dose without experiencing hypoglycemic side effects. Because vanadium is a trace mineral, over-consumption of vanadyl sulfate my also lead to toxicity. Vanadyl sulfate typically comes in 10 mg capsules or tablets, and a safe dosage range is believed to be 5-50 mg/day.


1. Novelli M, De Tata V, Fierabracci V, Barbera M, Rossetti R, & Masiello P. (2005). Comparative study on the preventing effects of oral vanadyl sulfate and dietary restriction on the age-related glucose intolerance in rats. Aging Clinical and Experimental Research. 17(5), 351-7.

2. Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, & Redondo JC. (2001). Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 86(3), 1410-7.

3. Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, & Kahn CR. (2000). Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism: Clinical and Experimental. 49(3), 400-10.

4. Willsky GR, Goldfine AB, Kostyniak PJ, McNeill JH, Yang LQ, Khan HR, & Crans DC. (2001). Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV). Journal of Inorganic Biochemistry. 85(1), 33-42.

5. Pandey SK, Anand-Srivastava MB, & Srivastava AK. (1998). Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation. Biochemistry. 37(19), 7006-14.

6. Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, & Rossetti L. (1995). Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 95(6), 2501-9.

7. Boden G, Chen X, Ruiz J, van Rossum GD, & Turco S. (1996). Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism: Clinical and Experimental. 45(9), 1130-5.

ABOUT THE AUTHOR: Cassie is a chemistry major and national level bodybuilder. Questions or comments? Talk to Cassie on the FORUM or on FACEBOOK.

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