Thymosin Beta 4 and TB 500
Thymosin Beta 4 is a research peptide which is based on a product of the thymus gland. This peptide is so small it can diffuse into places most peptides cannot. It facilitates angiogenesis and thus wound healing. Thymosin Beta 4 also down regulates inflammatory cytokines and helps with stem cell maturation. Thymosin Beta 4 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration which enables it to travel long distances through tissues.This means it stops the immune system from attacking damaged tissue, increases blood supply to that damaged tissue, attracts new cells to damaged tissue, and speeds new cells forming to replace old ones.
These healing effects can occur in, but not limited to; muscle, tendons, ligaments, skin, the heart, and the eye. Thymosin Beta 4 is produced in these tissues more than others so we know it works on them. It facilitates actin synthesis, Myocyte and Myoblast migration so in effect when it “heals” your muscles from damage induced by weight training you will grow more muscle. A synthetic version of Thymosin Beta 4 is on the market for race horses: TB-500.
A shorter synthetic version of Thymosin Beta 4, TB-500 is as effective for wound healing. Since this stuff actually works its not available legally for humans. It is legal to sell it if the intended patient is a animal, and thus TB-500 is a popular drug for horse racing. By no means is there a good scientific reason for humans not to use it, there are no known side effects. However It is still in its trials phase and isn’t FDA approved for humans yet.
3 mg every 3 days for 4 to 6 weeks is the standard dosing. Then a maintenance phase that is indefinite and at a lower dose.
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