Spironolactone is a mineralocorticoid receptor antagonist. This causes spironolactone to act as a mild diuretic. It is also used in topical form to help combat male pattern baldness because it also has some degree of antagonism at the androgen receptor. Many bodybuilders use diuretics such as lasix to help shed water for competitions. Lasix, however, is very harsh and can lead to serious health problems as witnessed in recent years as some bodybuilders have collapsed on stage and a few have even died from diuretic use. Spironolactone is a gentler diuretic that gets to the root cause of much of the water retention brought on by steroid use. Unfortunately, the anti-androgenic activity makes its use somewhat of a liability to the steroid-using athlete. Spironolactone will help to excrete some of the excess water from a cycle, which will result in lowered blood pressure. While potassium may need to be replaced while using lasix, it should never be given with spironolactone. Spironolactone will also help to prevent the negative cardiovascular effects of AAS by antagonizing excessive mineralocorticoid stimulation. As explained under eplerenone, some AAS have been reported to cause potassium retention so combination with an antimineralocorticoid may be ill advised since elevated blood potassium can cause a fatal heart attack.