Very few people want wrinkles. I dont think I know anyone myself. Do you? Would you like to know how you can decrease your wrinkles 34%?
Facial wrinkles occur from the continuous traction on the skin from facial muscles. The skin of the face is very special compared to other parts of the body in that the muscles interact with the skin in a very precise and delicate manner. Most of human communication is actually body language and facial expression, so humans evolved with facial expression being extremely complex and requiring a delicate precision of muscle/skin interaction.
Over years of expressing our emotions often involuntarily through facial expressions is that there are wrinkles left in the skin, which is considered by most to be less attractive than a young smooth face. Its to bad wrinkles aren’t considered cool; a testament of how long you managed to survive. Like emotional battle scars.
In order for muscle to contract it needs to receive a signal from the nervous system. It all comes down to the neuromuscular junction when discussing altering neuromuscular function. A presynaptic nerve releases Its acetylcholine and the acetylcholine binds to the muscle’s nicotinic receptors. This depolarizes the muscle
sarcoplasmic reticulum and calcium channels open allowing muscular contraction. An acetylcholine filled vesicle migrates from the presynaptic endoplasmic reticulum to the presynaptic cell surface to fuse with the cell membrane and deposit its contents of acetylcholine into the neuromuscular junction.
Its the SNARE protein complex, located on the inside of the presynaptic neuron cell membrane, which binds the presynaptic acetylcholine vesicle while it is still in the presynaptic nerve cell. This facilitates the vesicle fusing with the cell membrane. Like a dude cleaning a pool with a net grabbing floating beer cans, the SNARE is the dude and the net.
The SNARE is a complex of VAMP, Syntaxin, and SNAP-25.
SNAP – 8
SNAP -8 is so named because it is an 8 member carbon chain which inhibits the SNAP complex from binding the vesicle. The 8 carbon end of the SNAP-25 is synthesized to make SNAP-8. This is like swapping the net out for a net with a huge hole. This inhibits the vesicle from binding to the membrane and discharging its contents into the neuromuscular junction. The result is a lack of muscular contraction. This lack of muscular contraction in facial muscles prevents the tonic pull on the skin and prevents new and alleviates old wrinkles.
SNAP-8 can be applied to the skin topically and has reduced wrinkles around the eyes and other parts of the face by up to 34%. SNAP-8 is cheaper and safer than BOTOX and works in the same way. SNAP-8 can be made into all types of topical preparations, from creams to gels or whatever you want, as long as the concentration is the right amount it will work. The maximum reduction for 10% SNAP-8 solution was 63% less wrinkles.
Currently Its only available on the black market and it has to be injected not into the wrinkles themselves, but the muscles surrounding the wrinkles.
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