Is Fructus Schissandrae New Legal Steroids?
Fructus Shissandrae inhibits muscle atrophy almost as well as oxymetholone, the highly powerful anabolic steroid know as Anadrol 50. An extract of Fructus Schisandrae, the dried fruit of the plant Schisandra chinensis, protects muscles from atrophying. It makes this compound highly anti-catabolic, not anabolic. Would this make this a possible replacement of legal steroids?
Study on Fructus Shissandrae, A Possible Replacement Of Legal Steroids
The experiment lasted 24 days in total. From day 14-24 the researchers injected most of the mice daily with the muscle-wasting corticosteroid dexamethasone. They did this to imitate situations in which muscles break down more rapidly as a result of overexertion, poisoning, illness or aging. Some mice were given 50 mg per kg bodyweight of the steroid oxymetholone daily from day 1. The human equivalent of this dose would be about 500-600 mg per day, which is a ridiculously high amount. This powerful anabolic steroid was administered orally. This amount would be certainly bring about some very negative side effects.
Some other mice were given Other mice were given 125, 250 or 500 mg per kg bodyweight of an ethanol extract of Fructus Schisandrae daily commencing on day 1. Human equivalent doses would be about 1500, 3000 and 6000 mg per day. Traditional healers and supplement manufacturers recommend that the lowest dosage be used for patients and athletes. A placebo was given to a control group.
Results And Conclusion
Dexamethasone caused a reduction in both size and strength of the mice’s calf muscles. Oxymetholone and the Fructus Schisandrae both reduced this effect. The highest dose of Fructus Schisandrae was almost the same anti-catabolic effect as oxymetholone. That is mind blowing stuff. Dexamethasone increases the enzymes LDK and CK in the blood, biomarkers of muscle damage. Oxymetholone and Fructus Schisandrae both reduced the concentration of the enzymes. Dexamethasone also lowered antioxidant enzymes in the muscle cells, but oxymetholone and Fructus Schisandrae reduced the effect. Dexamethasone boosted the synthesis of catabolic muscle proteins such as myostatin, MuRF-1 and Atrogin-1. Oxymetholone and Fructus Schisandrae reduced this effect. We will keep an eye on this promising dietary supplement. Lastly, dexamethasone boosted the synthesis of catabolic muscle proteins such as myostatin, MuRF-1 and Atrogin-1. The highest dose tested may not be safe for humans. It could be possible for athletes to inhibit muscle atrophy by combining reasonable doses of Fructus Schisandrae with other anti-catabolics such as curcumin or HMB.