MGF: Mechano Growth Factor

Detailed gene expression of MGF from IGF-1 Exons

Detailed gene expression of MGF from IGF-1 Exons


Mechano Growth Factor is awesome.  It is made WHILE you’re lifting. Thats right, in the middle of the set your muscle cells are making MGF from your RNA.  For years we’ve been told “you don’t grow in the gym” but it turns out your body is trying to.  MGF is made from IGF RNA with a modification.  It is also called IGF-1Ec.  This version of IGF-1, MGF, acts immediately on the stem cells called satellite cells to have them donate nuclei to the muscle cells. This now allows the muscle cell to get bigger.  Drop sets in particular are believed to be responsible for MGF synthesis.  After this initial response other versions of IGF are made from the liver to boost muscle cell growth.  



Some researchers deny the existence of MGF in the body. They claim it could exist but we haven’t proven it exists, and if so not in the synthetic MGF form.  These scientists reject the name MGF and claim it should be called IGF-1Ec. Im serious, there are people angry and complaining that IGF-1Ec got a different name from the other IGF-1Es.  If you name one why not name them all right?  They acknowledge that synthetic MGF does work on a separate pathway (ERK) than the IGFs (AKT), and they don’t have a problem with the synthetic being named MGF, Their complaint is when IGF-1Ec is called MGF until its proven to be, and do, the exact same thing inside the cell.  


In humans and mice it was found that less MGF was present in exercised tissues of elderly members of the species than in young adult members.  When Growth Hormone (GH) was administered to elderly humans long term their MGF levels were much closer to the younger human subjects. This seems to indicate that GH or a downstream effect of GH causes more MGF to be released during exercise.  


Forum suggested dosage is about 100 mcg of synthetic MGF in a lagging muscle post workout.  Very similar to IGF -1 dosing. This is not surprising as this is very similar in function as well as structure to IGF-1.  

Let me point out that getting your dose off a forum is a very scary and not smart thing to do. But sometimes they are the only doses available. In other words there are many breaks in the chain of certainty, lots of things that could be assumed true and is actually false.   

Gene Doping

A study on rats found that a single injection increased muscle size by 25%.  This is through a viral vector of MGF cDNA modified to amplify expression. There is a way of detecting if the person has received the injection built in, so if in the future sports regulating bodies try to control gene doping.  


MGF is a version of IGF -1 that is produced during resistance training. It causes satellite cells to migrate to the muscle cell and donate a nucleus.  This causes muscle to grow. There are synthetic versions of MGF and MGF gene doping experiments being conducted.  To increase the effectiveness of MGF, Increase your IGF-1 receptors with Wyked 2.1!

Nothing in this article or on this site should be considered medical advice or as an endorsement to violate any law of the country in which you reside.  The information given is for fun and entertainment purposes only.  All claims are 100% dependent upon proper diet and exercise.  Please consult a medical practitioner prior to any diet and exercise program.

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