Stacking Laxogenin, Ecdysteroids and Brassinosteroids with Prohormones 101 - Mind And Muscle

brassinolideEveryone wants to squeeze every last bit of size and strength out of a prohormone cycle   Prohormones represent the Laxogenin and 5-Hydroxy-Laxogenin are steroid like plant molecules that induce growth in various plants. Over the years there have been numerous plant based discoveries that seem to have anabolic properties and can safely be stacked with modern prohormones to provide an additive effect.  Ecdysterone is a bug steroid that may be active in human beings and can build muscle mass. Brassinosteroids are similar plant based steroids that seem to boost testosterone and work under similar pathways. These plant steroids typically work on a different pathway compared to traditional anabolic steroids or prohormones and downstream pathways are perfect when stacking and in some individuals they can actually rival anabolic steroids in gains.

Laxogenin and 5-Hydroxy-Laxogenin

These are steroidal sapogenins that can activate a pathway called PIK3 which is the initiator of the mTOR process to muscle growth that is impacted by BCAA’s.  These steroidal molecules can work in addition to other steroidal molecules to help accelerate muscle growth and protein synthesis.  These ingredients are expensive so watch out for any bargain supplements.   This would be good to stack with any prohormone especially wet compounds like 4-Andro and 5-Andro.  A decent dose is 150mg per day.


Beta-Ecdysterone has been studied and debated for years.  It has been shown to increase grip strength and strength along with increasing protein synthesis.  A recent study shows that it selectively activates the ER-beta estrogen receptor while increasing IGF-1 and other important co-factors.  This shows that estrogen can increase muscle cell size but only the beta receptor is active in this process.  Ecdysterone has enough data behind it to give it a good rating as a supplement.  A good dose is 300-600mg of pure ecdysterone. This would stack really well with dry prohormones like 1-Andro or Epi-Andro.


These molecules are probably the best items that we can stack with prohormones.  They are truly wonder anabolics because they boost testosterone by increasing the activity of many key enzymes in the body which convert prohormones to active steroids. They are also anabolic in a similar way to the Laxogenin series.   This is sound theory and was also tested in a supplement which gave an increase in testosterone and muscle mass.  28-Homobrassinolide seems to be the molecule that we want to stack with prohormones.  Sadly there isn’t much in the way of a pure product that we can use at this point, but maybe one day soon.

Wrap Up

That wraps up the non-androgenic steroidal products that can be effectively stacked with prohormones.  Certainly the most interesting is the 28-Homobrassinolide but both Laxogenin and Ecdysterone have their place with prohormones.  For anabolic steroids the situation is a bit different.  The best choice would be the 5-Hydroxy-Laxogenin along with the Ecdysterone coming in a distant second, especially if you are using something like Testosterone.  With steroids the 28-Homobrassinolide wouldn’t be as useful because it may convert the active androgens into less active metabolites.  The data does show that these plant based steroidal molecules can actually do some amazing things for muscle growth and repair along with strength and performance.  Be sure to use quality extracts from reputable companies.


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