L-Alanyl-L-Glutamine Enhances Rehydration and Improves Endurance Performance

Guy and weight benchL-Alanyl-L-Glutamine is also known as “Sustamine”. A study published in 2010 in the Journal of the International Society of Sports Nutrition Examined the effects of supplementation with L-alanyl-L-glutamine on performance when used to aid rehydration.

10 male subjects participated in the study. After performing a baseline exercise test cycling at 75% of VO2 max, the performance of the subjects during the same test was examined under a variety of conditions including a dehydrated state as well as dehydrated and then rehydrated with either water, water with 0.05g/kg body weight of L-alanyl-L-glutamine, and water with 2g/kg body weight of L-alanyl-L-glutamine.

The researchers compared blood samples from various points during the trials and observed the differences in performance between the two groups. They found that the when the subjects were rehydrated with the addition of L-alanyl-L-glutamine, they were able to cycle for a longer period of time before becoming exhausted than when they were rehydrated with only water. This result was likely due to the L-alanyl-L-glutamine aiding in the uptake of fluids and electrolytes. These results suggest that L-alanyl-L-glutamine may be of benefit to endurance athletes to maintain proper hydration and therefore maintain performance during exercise.



Hoffman JR, Ratamess NA, Kang J, Rashti SL, Kelly N, Gonzalez AM, Stec M, Anderson S, Bailey BL, Yamamoto LM, Hom LL, Kupchak BR, Faigenbaum AD, & Maresh CM. (2010). Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. Journal of the International Society of Sports Nutrition. 7, 8.

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