Insulin Sensitivity - Part 2

Don't let insulin resistance kill you, increase your sensitivity to insulin!

Don’t let insulin resistance kill you, increase your sensitivity to insulin!

Continued from part 1

Insulin Replacers

The holy grail would be something that caused the Glut4 transporters on the muscles to upregulate, thus increasing the muscle’s insulin sensitivity. This means you could consume lower GI carbs and get the same or better muscle gains with less fat storage. The next best thing would be something that increased the sensitivity of the pre existing Glut4 transporters on the muscles. Obviously more transporters that are more sensitive is at least 4 times better.

The problem in the past is if you use the carbs with super low GI indexes they get burnt for fuel before ever getting in the muscle. If we could increase the insulin sensitivity with supplements or extend the “Anabolic Window” when Glut4 transporters are most sensitive from 2 hours to 6 that would help with fat free gains as well.


6 Mass:

This is a 6 keto Pregnenolone which shifts this balance. Like omega 3s it is a proven nutrient partitioner: it diverts carbs from going to the fat cells to going into muscle cells. Lets say you store 60% of your post workout carbs as glycogen in the muscle and the other 40% as glycerol in fat cells. 6-Mass would increase this ratio to 70:30 from 60:40 for example. Lower the insulin response to the carbs and further improve this ratio, or improve the muscle’s insulin sensitivity through modifying the expression or activity of the glut4 transporters.


Omega 3s:

These are proven nutrient partitioners and insulin sensitizers. DHA and EPA provide a myriad of health benefits, and come from fish. ALA is different though. It is an Omega 3 but does not do the same things as the DHA and EPA, it is refined from flax typically.
Alpha Lipoic Acid (ALA) is an antioxidant. It regenerates Vitamins E and C after your body uses them to fight oxidative damage from lifting like a beast. That’s why they are called ANTI-oxidants. It also regenerates COQ10 and NAD.

Like everything else in this class the evidence is mixed. In some studies diabetic’s blood sugar was lowered by ALA administration, but in others it isn’t. Its really funny, I’m reading WebMD and they have all these unrelated seemingly silly abilities attributed to ALA but they don’t tie them together. Its really simple, the reason why ALA can decrease body fat, improve healing, and decrease diabetic nerve pain after 4 weeks is it DOES drive carbohydrates into tissues.

If it walks like a duck, quacks like a duck and some double blind experiments proved its a duck then just because some studies did not PROVE it was a duck doesn’t DISPROVE the ones which DID. Of course to add insult to retarded injury, WebMD warns people it might cause hypoglycemia. Let me get this straight, you’re not sure it does anything, but its dangerous because it can lower your blood sugar? But you just said you’re not sure it lowers blood sugar? Such cowardly nonsense, grow a pair and commit. You have to believe it lowers blood sugar before its lowering of blood sugar is dangerous. So stupid. And these are my “peers” lacking the common sense of a 5 year old: “If dragon fire isn’t real then it can’t burn you. My burn is real though, so the fire must be real and thus so was the dragon.”

It should have said “ We have inconclusive evidence but mountains of anecdotal evidence and overdoses have been recorded so it must lower blood sugar somehow.”

Another warning is that it can be very harmful in the absence of B1 (thiamin). Because people who buy obscure shit like ALA aren’t taking multivitamins.

Don’t take ALA if you’re having chemotherapy, the ALA is so good for your it slows down the rate chemotherapy kills you, i mean your cells. Can’t have that.

No I looked at another layperson site which is marketed as a medical site, and it was way more clear and straightforward. Dr. Weil obviously doesn’t have his balls in his lawyers purse like the people at WebMD do.

My conclusion is like other Omega-3s, GLA, and everything else in this class ALA increases insulin sensitivity. Or it decreases elevated insulin resistance back to a sensitive base line more precisely. All the studies were done on diabetics (insulin resistant) that had shown a positive result (27% more glucose clearance). Studies on non diabetics showed no improvement on glucose clearance. I would like to add only with the addition of diabetes meds will you get a hypoglycemic episode if this is true, that it normalizes insulin resistance not increases sensitivity.

In a study on the more active Omega 3s DHA and EPA, it was found that using insulin + BCAA in people treated with Omega-3s gained 33% more protein synthesis than the untreated group.


Vanadyl Sulfate:

Vanadyl sulfate was found to increase the responsiveness of muscle to insulin and amplifies insulin’s effects on muscle. It both signals the receptors and upregulates the receptors. Vanadyl sulfate decreases fasting glucose by 20% when taken at 50 mg a day 2 times a day. It did reverse the flow of glucose from out of the liver to into the liver.

Despite this the experiments on humans found no greater glycogen synthesis. Regardless of their tested population of diabetics In OUR population of lifters and people who bust their ass if you turn the insulin sensitivity of muscle up then you direct more carbs to muscle and less to fat. Period.


Chromium Picolinate:

There is a lot of controversy surrounding this “essential mineral”. It has been on the chopping block and this is why: Although it was considered an essential mineral there is none found in the body of someone who does not supplement with it. furthermore there is no known beneficial effect except that it does decrease the membrane rigidity of the muscle cells phospholipid bilayer and this causes the insulin receptor to be more sensitive. The medically recommended amount is 200 mcg per day but overdoses have been reported. the reason people are considering it more harm than good is when in high doses it binds to the transcription element inside the cell and slows DNA transcription into mRNA. Chromium D-glucosaminic acid is as effective as Chromium picolinate in treating diabetes.

Again, the only tested population were diabetic people to see if it caused their elevated blood sugar from insulin resistance to go down to a closer to normal level. when given to people who are not diabetic nothing happens. In a body builder who is slamming post workout carbs this is a different story, he is temporarily hyperglycemic and thus it may help. Additionally why would any of these supplements cause glycogen synthesis in a sedentary person: they have full glycogen stores!!! You can’t fill a full glass. Dumbasses. Try testing glycogen depleted post workout athletes with a carb drink and I am pretty confident they will have more glycogen at the 4 hour mark than those who didn’t take chromium.



Cinnamon comes from the bark of a southeast Asian evergreen tree. One teaspoon contains over a gram of fiber, plus iron, manganese, and vitamins C and K. Cinnamon, at a dose of 3 g per day, decreased blood glucose levels in type 2 diabetics. In one study, cinnamon decreased Hba1c and lowered blood pressure at a dose of 2 grams per day it also lowered LDL cholesterol at ½ tsp per day.

Another small study showed that cinnamon improved blood sugars in patients with polycystic ovarian disease (PCOS). This is common sense since it is highly unlikely that anyone with PCOS isn’t insulin resistant. It is a disease similar to Diabetes II but the difference is instead of too much glucose and insulin the woman has too much estrogen and it is back converting into testosterone. How do we get to much estrogen kids? Thats right, excessive body fat!

considering the population tested it may not be a good thing that Cinnamon may improve appetite and relieve indigestion.

Side effects are rare when it is used as a food additive at normal doses. It has a bunch of nonsense concerns on the cleveland clinic website which are too silly to list here. my favorite is that it doesn’t help with Type 1 Diabetes. this shows it isnt a insulin mimicking compound but instead improves insulin sensitivity. Type 1 diabetics aren’t insulin resistant remember? they were born incapable of making insulin so they are actually super insulin sensitive…until they are prescribed injectable insulin.



As you can see Resistance exercise is so much better than aerobics it makes aerobics look worthless. and all you do by adding your aerobics to a resistance routine is cut your gains in half, with no signifigant increase in fat burning.

As you can see Resistance exercise is so much better than aerobics it makes aerobics look worthless. and all you do by adding your aerobics to a resistance routine is cut your gains in half, with no signifigant increase in fat burning.

To get the best body possible and the bonus effect of being healthier:

*Lower your insulin resistance/raise your insulin sensitivity

*Keep your body fat below 15%

*Lift weights the way I say to (Click here for training)

*Use 2 g Cinnamon, 600 mg R-ALA, 200 mcg Chromium, and 50 mg Vanadyl Sulfate post workout to increase your carb delivery to the muscle by increasing your insulin sensitivity. Its possible this wont help healthy people, but we won’t know until we test it on healthy people not just diabetics lol. My personal experience is the Chromium and Cinnamon work like gangbusters, never tried the other two.

*Stay away from processed or high GI foods. True, You can absorb more post workout but to guarantee you gain the least amount of fat don’t spike your post workout insulin, just have the 30 g of carbs 30 minutes post workout from a medium source like sweet potato. Or white potato if you’re Dom Mazzetti.

My references:

The references of the references:

“Cinnamon.” Natural Standard –The Authority on Integrative Medicine. Natural Standard, 2013.
“Cassia Cinnamon.” Natural Medicines Comprehensive Database. Therapeutic Research Faculty, 2013. 8 November 2013.
Wondrak, G.T. et al. The Cinnamon-derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-dependent Antioxidant Response in Human Epithelial Colon Cells. Molecules 2010 15(5) 3338-3355
Kwon, H. et al. Cinnamon extract induces tumor cell death through inhibition of NFKB and AP1. BMC Cancer (2010) 10:392
Roussel, A. et al. Antioxidant Effects of a Cinnamon Extract in People with Impaired Fasting Glucose That Are Overweight or Obese. Journal of the American College of Nutrition (2009) 28, 16-21
Qin, B. et al. Cinnamon: Potential Role in the Prevention of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes. Journal of Diabetes Science and Technology (2010) 4, 685-693

Nothing in this article or on this site should be considered medical advice or as an endorsement to violate any law of the country in which you reside. The information given is for fun and entertainment purposes only. All claims are 100% dependent upon proper diet and exercise. Please consult a medical practitioner prior to any diet and exercise program.

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