Hypertrophy and Hyperplasia The Process Of Muscle Growth


No its not me, it’s Lee Priest. Way cooler!

When I was in medical school there was a textbook of physiology, Guyton & Hall,  that was considered the bible of human physiology.  In this book it states humans can only grow their existing muscle tissue 30% larger and cannot grow new muscle fibers or cells.

What a bunch of horse shit. If this was the case how would you have 300 pound bodybuilders?


Hypertrophy vs. Hyperplasia

Hypertrophy means increased growth. Hyperplasia means increased formation. There are several mechanisms for muscle tissue to develop but i will focus on the outcome and how modern medical science is not only wrong at a theoretical level but overlooks the painfully obvious data: real life.  



A muscle cell grows from many factors, but in the end it has to do with a few key components.  Cells swell and grow larger in volume (hypertrophy) from increased water accumulation in the cell.  This is achieved from hormones driving water into the cell directly like testosterone and DHT and from solutes being driven into the cell by hormones; amino acids and carbohydrates being driven in by insulin.  Hormones like estrogen cause cells to stretch partly through IGF-1 and the migration of satellite cells to the surface of the muscle cell and donating a nucleus.  A satellite cell is like a dormant stem cell and has many nuclei to donate.   Muscle cells are special in that they have many nuclei.  These nuclei allow for more protein synthesis within the muscle cell.  Now when testosterone binds to the androgen receptor it has more nuclei to migrate to which allows for faster protein synthesis.  These proteins are the contractile elements that actually do the work in the muscle of muscular contraction.  MUSCLE PROTEIN HAS LITTLE TO DO WITH MUSCLE SIZE, It is for muscle STRENGTH.  Size comes from how much water and glycogen is stored in the muscle.  



When a muscle cell becomes so large it can’t swell anymore, it will divide into two smaller cells. That is Hyperplasia. Now those 2 smaller cells can begin to grow through more hypertrophy.  And subsequently there can eventually be more muscle protein and greater strength from the muscles being larger.  

To reiterate: Muscle strength does not generate size, size permits the potential for strength however.


Upward Spiral Of Getting Swole

The volume of work you do helps the muscle to generate more mitochondria: more nuclei from satellite cell donation means more mitochondria. More mitochondria means more work capacity. more work capacity means more volume can be performed before fainting and or vomiting. More volume means more satellite cell migration. More satellite cells means more nuclei, more nuclei means more mitochondria. etc. Forever in theory.

How does this actually cause Hypertrophy? The more volume in your workouts the more glycogen you need. So your muscles adapt to hold more glycogen. With each mol of glycogen there are 3 mols of water which enter the cell osmotically.   This intracellular stretching from the water eventually leads to cell splitting (Hyperplasia).


Please Note:

Intensity releases growth factors like IGF-1 and MGF among others. These are critical elements in the muscle growth process. Just flailing away with light weight for hours may be voluminous but not intense and thus useless.  People who lift without intensity are like a 4 year old playing in the drivers seat when you have the keys in your pocket: they go nowhere. Most gym goers are equally oblivious of the futility of their efforts. They plod along with their useless routines and half measures and accomplish nothing. Years turn into decades and they look no better, only older.  If you’re not crying, bleeding, or puking your not working out, you’re just in the way.

Creatine has been clinically proven to drive water into the cell and cause splitting. Testosterone has as well.  The reason Super Drol, M-Drol, and Halodrol were so popular is they put on a ton of water weight. But the water weight was in the muscle not under the skin like D-Bol.  

The Mind And Muscle Basic Mass Stack will have an efficient blend of testosterone and estrogen to stimulate all the mechanism for muscle hypertrophy and eventually hyperplasia.  Assuming you lift like there is a gun to your head of course.


Nothing in this article or on this site should be considered medical advice or as an endorsement to violate any law of the country in which you reside.  The information given is for fun and entertainment purposes only.  All claims are 100% dependent upon proper diet and exercise.  Please consult a medical practitioner prior to any diet and exercise program.


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