Stimulants: Evodiamine - Mind And Muscle

guy lifting heavy weightsEvodiamine is a constituent of the Evodia Fruit (Euodia Ruticarpa). Evodia Fruit has been used in traditional Chinese medicine for many purposes including weight loss and energy. Evodiamine has been shown to be a stimulant, diuretic, and thermogenic and it has also been shown to reduce the absorption of dietary fat. Anecdotal evidence shows evodiamine to be an appetite suppressant as well. All of these effects of evodiamine make it a good addition to a fat burning or energy supplement.

The stimulant and appetite suppressant effects of evodiamine can be attributed to its effects on catecholamine levels. Evodiamine increases the release of catecholamines such as adrenaline and dopamine from the adrenal glands, increasing energy levels and decreasing appetite. Evodiamine has been found to increase heat loss (thermogenic effect), which means that more calories are being burned and can result in weight loss. This thermogenic effect is greater than that of other stimulants such as caffeine so it must have to do with more than just catecholamine release, but at this point its mechanism is not fully understood. Evodiamine has also been shown to reduce the absorption of dietary fat, so not only are more calories burned but less are also absorbed. One additional benefit of evodiamine is that it may have a diuretic effect due to the inhibition of aldosterone release (aldosterone essentially signals the body to retain water). This rids the body of excess water retention for a leaner look. Diuretics generally only work for a short amount of time, but nevertheless this is still a possible use for evodiamine.

The potential benefits of evodiamine are numerous, but unfortunately the human studies are seriously lacking. What we know about evodiamine is a result of animal studies. The anecdotal evidence definitely does seem to support the use of evodiamine as a stimulant, thermogenic, and appetite suppressant, and it is included in many fat burning and energy supplements for these purposes.

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1. Wang T, Wang Y, Kontani Y, Kobayashi Y, Sato Y, Mori N, & Yamashita H. (2008). Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling. Endocrinology. 149(1), 358-66.

2. Shi J, Yan J, Lei Q, Zhao J, Chen K, Yang D, Zhao X, & Zhang Y. (2009). Intragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats. Brain Research. 1247, 71-8.

3. Bak EJ, Park HG, Kim JM, Kim JM, Yoo YJ, & Cha JH. (2010). Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes. International Journal of Obesity (2005). 34(2), 250-60.

4. Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, & Blumberg PM. (2004). Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Organic & Biomolecular Chemistry. 2(16), 2281-6.

5. Hung PH, Lin LC, Wang GJ, Chen CF, & Wang PS. (2001). Inhibitory effect of evodiamine on aldosterone release by Zona glomerulosa cells in male rats. The Chinese Journal of Physiology. 44(2), 53-7.

6. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, & Kamiya T. (2001). Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Medica. 67(7), 628-33.

7. Yoshizumi M, Houchi H, Ishimura Y, Hirose M, Kitagawa T, Tsuchiya K, Minakuchi K, & Tamaki T. (1997). Effect of evodiamine on catecholamine secretion from bovine adrenal medulla. The Journal of Medical Investigation : JMI. 44(1-2), 79-82.

ABOUT THE AUTHOR: Cassie is a chemistry major and national level bodybuilder. Questions or comments? Talk to Cassie on the FORUM or on FACEBOOK.

DISCLAIMER: The information on this website reflects the opinion of our staff and manufacturer’s and should not be interpreted as medical advice. The information is not unbiased or independent and is the opinion of the owners of The descriptions and statements accompanying these products and vitamin supplements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.

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