Estrogen: Necessary for Prostate Cancer

If you want Prostate cancer then Estrogen is for you! Turns out prostate cancer cant really exist without estrogen.

If you want Prostate cancer then Estrogen is for you! Turns out prostate cancer can’t exist without estrogen.

What is Cancer?

Cancer is a strange name for a disease.  Cancer is an astrological sign for people born in late june and july.  Cancer is also the name for crab in Latin. The disease Cancer was named after the shape of the tumor as it spread into other tissues, like a crab.  

Not all tumors are cancerous, but all cancers are tumors.  Stem cells can grow into different types and that process is called differentiation.  Bone is different than muscle, but they came from the same stem cells.

Muscle grows in two ways: Hypertrophy, and Hyperplasia.  HyperTrophy means more growth. This is when the muscle cell gets bigger or swells with carbs protein and water.  Hyperplasia means more formation. This is when stem cells called satellite cells donate nuclei to the muscle cells and they swell large enough to divide into new cells. In no way is this growth a tumor or a cancer, it is fully differentiated tissue growing as its supposed to.  

NeoPlasia, or NEW growth, is the name when a non or partially differentiated cell line is growing in a way it is NOT supposed to.  Cells normally self destruct when they take too much environmental damage and the DNA is compromised, but when the DNA for self destruction is compromised then the cells can take on a life of their own.  Tumor is latin for swelling, and a tumor is benign if the neoplastic mass grows but does not spread. Once it either sends forth tendrils to grow into other tissue or fragments off and spreads through the lymph or blood stream then it is now MALIGNANT, and thus a CANCEROUS Tumor.  

I could go on and on about cancer for hours.  It is one of the most breathtakingly calculating destructive forces found in nature. Its ability to generate its own immortality and its seemingly endless drive to grow, destroy, and kill is shocking. But the most interesting part is this: since the tissue is not differentiated fully every single cancer cell has the potential to turn into and or adopt the functions of just about any other cell.  

For example; Claire on Heroes could regenerate. Thats one of the best powers but its only one power, she can’t get more. My man Sylar had the power to learn other characters powers by examining their brains. He could learn Claire’s power and dozens more.  Now imagine if Sylar didn’t need to examine the brains of anyone, he could just manifest any power he needed at the time to survive, feed, or to kill as many people as possible. If that was Syler’s power we would rename him Cancer.

The first step to defeating your enemy is to know it. The more differentiated a tumor is, the more predictable.  Without knowing what the primary site of a tumor is you can’t predict what tissue it is (short of biopsy) or how to kill it…before it kills you.  


What’s a Prostate?

The prostate is a gland inside men at the base of the penis.  It is a critical gland for sexual performance and ejaculation.  I could get into a myriad of details about the prostate gland but lets stick to how it gets cancer.

The old model is that prostate cancer is caused by DiHydroTestosterone or DHT binding to the prostate cell. That all men if they live long enough WILL get prostate cancer.  That treatments are to block the androgen receptor (all over the body not just the prostate) and to stop testosterone from converting into DHT through Proscar (5mg finasteride).  This was how propecia was discovered (1mg Finasteride), men with prostate cancer were regrowing hair as hair follicles are another damaging binding site of the DHT molecule.  Turns out, like everything else in endocrinology, the truth is far more complicated and far far darker.  


Estrogen is a metabolite of testosterone and is the key female hormone. There are three types: Estrone, Estradiol, and Estratriol.  Estradiol is the strongest of the three at eliciting an estrogen effect. Estradiol-17β (estrogen) has been classified as a carcinogen by the International Agency for Research on Cancer.  Estrogens are prevalent in our environment.  Plastic containers, hormones fed to livestock and fish, and soy are major carcinogens in our environment. The problem is so severe that the age of puberty for women was moved from 13 when I was a kid to 9 now.  Additionally the average penis size is 5.5 inches now but was 6.5 inches 100 years ago. Women, make sure to feed your kids processed food and milk if you want your daughter’s knocked up at 14 and your sons to have smaller junk.  

Aromatase is the enzyme that converts testosterone to estrogens. It is also known as CYP19.  It sucks.

The prostate gland has its own version of aromatase; CYP19A1 instead of the usual CYP19 found in other tissues.  This means that the prostate makes its own estrogen.  Mice which have no aromatase enzyme had far less prostate cancer than mice with aromatase, even when these Knockout mice were bombarded with estrogen and testosterone.  Additionally when the prostate cancer spreads to other parts of the body it up regulates the CYP19A1 expression 30 fold!  Like it turns up production of estrogen so the cancer seeds in other tissue grow faster. As if estrogen is water to the seeds.  Sounds like something Sylar would do.

1nM of Estradiol was found to cause prostate progenitor cells (semi-differentiated prostate cells) to grow. Prostate cells do not grow in the presence of testosterone and the absence of estrogens and DHT alone has a minimal effect.  Additionally the part of the prostate which gets the tumor growth is the part which has the most aromatase: the part that makes the most estrogen.

The case is brutally clear against estrogen.  

Additionally I found research that shows that the prostate has a Sex Hormone Binding Globulin (SHBG) receptor on it. But this is the crazy part: The SHBG molecule cannot bind to its OWN RECEPTOR! That is, not until SHBG binds to estrogen.  This combination changes the shape of the SHBG molecule and NOW it can bind to the prostate. But it doesn’t do anything by itself…confused yet? When this complex of estrogen and SHBG binds to the SHBG receptor it will amplify the carcinogenic effect of DHT when DHT binds to the androgen receptor.  In other words estrogen is really the culprit behind the belief that DHT causes prostate cancer.  


Want To Be More Confused?

Remember how it was believed that DHT was the main instigator for prostate cancer? Well get this: the medication used to stop DHT production actually causes it to be permanently reduced in about 6% of the people who use it (Post Finasteride Syndrome).  Aside from sexual function problems, depression, exhaustion, and some claim penis size reduction (that sounds like an excuse) It causes an upregulation of estrogen production!  Why? Simple. DHT inhibits Aromatase…less DHT = more aromatase = more estrogen.  


What The Hell Are You Talking About?

Let me summarize; for years doctors have used Finasteride in a slash and burn campaign ravaging the patients body in an attempt to stop DHT and its binding to the prostate. It turns out that it was estrogen which was a bigger contributor to prostate cancer after all! and the prostate gets high on its own supply. Thats right, the prostate makes its own estrogen inside the gland so free estrogen levels cannot indicate a threat.  To make matters worse the drug the doctors were giving to stop DHT INCREASED the activity of the estrogen production and in 6% of people this increase is  permanent.  


Still Lost?

Doctors gave a drug to men to cure prostate cancer but were aiming in the wrong direction and it made the real problem worse, and irreversible and permanent in a small percentage of men.  


So What Is The Treatment?

Based on the data from the mice who had no aromatase, the inhibition of aromatase is the key to helping these men ESPECIALLY those who are being treated with a 5AR like Finasteride.  

If you’re concerned about your prostate then thats just another reason to be on an aromatase inhibitor. I have been for 5 years now.  I’m a man, why would I want a female hormone? especially one that causes fat accumulation, water retention, moodiness, smooth muscle relaxation, prostate cancer, breast tissue growth, breast cancer,  and worst of all is made from testosterone.  Letting your body turn testosterone into estrogen is like turning gold into feces then having to eat it.  

There are 3 aromatase inhibitors in the Mind and Muscle store: Arom-X, 35-AI, and Form-XT. All work great, are safe, and are legal.  No prescription, no lab tests, just the best defense you can use against your body self destructing from the deadly ravages of estrogen.  

Nothing in this article or on this site should be considered medical advice or as an endorsement to violate any law of the country in which you reside.  The information given is for fun and entertainment purposes only.  All claims are 100% dependent upon proper diet and exercise.  Please consult a medical practitioner prior to any diet and exercise program.

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