Does D-Aspartic Acid Boost Testosterone? - Mind And Muscle

This question has been posted on the forums and asked in supplement shops around the country.  D-Aspartic Acid was all the rage in supplements a few years ago and it’s sadly fallen off the map even though the right form of it absolutely boosts testosterone.


As usual, there are so many “hacks” in the sports nutrition industry and of course people just read the headline “D-Aspartic Acid” and started making supplements.  Only Patrick Arnold ACTUALLY read the study and told everyone that standard DAA wouldn’t work that in fact you would need to use the D-Aspartate form to actually get the proper response you want!  What that means is that 99% of the D-Aspartic Acid supplements on the market don’t work and that you are wasting your time and your money taking DAA supplements that don’t contain either Sodium D-Aspartate or Calcium D-Aspartate.  These two supplements are the only two to actually contain the active form that boosts testosterone.


What’s one atom (Hydrogen) going to do to a supplement?  Well, if you know anything about supplements…a ton!  What separates Testosterone (active obviously) from Androstenedione (inactive) is simply one Hydrogen away.

Andro Testosterone

So, as you see one simple Hydrogen (the H on the right of the testosterone molecule) can make a huge difference.  Thus since it is possible that one hydrogen can make a vast difference, then perhaps we have the same situation in D-Aspartic Acid.


If you look at the literature it will tell you the same thing.  The studies that show an increase in testosterone use the D-Aspartate form and the studies that show no activity use the Acid subtype.  Thus, you can see why so many people were disappointed using the D-Aspartic Acid products and ones that took D-Aspartate had great results.

One (or two in this case) atoms of hydrogen can have a profound effect on the activity of a molecule, so make sure you use the proper form.

Active Forms:

Sodium D-Aspartate

Calcium D-Aspartate

Inactive Form:

D-Aspartic Acid


J Endocrinol Invest. 2016 Feb;39(2):207-13. doi: 10.1007/s40618-015-0333-4. Epub 2015 Jun 28.
D-Aspartic acid stimulates steroidogenesis through the delay of LH receptor internalization in a mammalian Leydig cell line. Di Nisio A1, De Toni L1, Ferigo M2, Rocca MS1, Speltra E1, Ferlin A1, Foresta C3.

J Int Soc Sports Nutr. 2015 Apr 1;12:15. doi: 10.1186/s12970-015-0078-7. eCollection 2015.
Three and six grams supplementation of d-aspartic acid in resistance trained men.
MelviSteroids. 2014 Jun;84:103-10. doi: 10.1016/j.steroids.2014.03.016. Epub 2014 Apr 5.

Stimulation of androgen production by D-aspartate through the enhancement of StAR, P450scc and 3β-HSD mRNA levels in vivo rat testis and in culture of immature rat Leydig cells.
Raucci F1, D’Aniello A2, Di Fiore MM2.lle GW1, Siegler JC1, Marshall PW1.

Nutr Res. 2013 Oct;33(10):803-10. doi: 10.1016/j.nutres.2013.07.010. Epub 2013 Aug 15.
D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men.
Willoughby DS1, Leutholtz B.


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