ALT - 711

ALT -711 AKA Alagebrium was touted as an anti aging drug, but now is tested for erectile dysfunction.

ALT -711 AKA Alagebrium was touted as an anti aging drug, but now is tested for erectile dysfunction.


Alagebrium (ALT-711) is an AGE-breaker, a compound that dissolves some forms of advanced glycation end-products (AGEs), compounds implicated in the damage of aging. Extensive research was done on this compound as a possible fountain of youth, a fabled way to live forever disease free.  

Unfortunately ALT-711 was abandoned during human trials due to it having little use in humans. It seems AGEs play a bigger role in rats than in humans.

Despite this, there is still research being conducted to see how cardiovascular health of diabetics and erectile dysfunction can be treated with ALT – 711.

This diagram shows where ALT-711 blocks crosslinking

This diagram shows where ALT-711 blocks crosslinking


In one study ALT-711 was shown to increase vascular health in treated diabetic rats when compared to control diabetic rats.  

In another study ALT-711 was tested with viagra to see if it would amplify the effects of viagra.  Diabetic rats were tested and it was shown that ALT-711 with Viagra is better than Viagra alone.  

If it doesn’t work in humans but only in rats then why test it? I can see that it is a great compound if you’re a diabetic rat with heart disease or with erectile dysfunction.  

Well there was one study done on cardiovascular health of elderly humans in 2001. In this study they found that ALT-711 decreased the systolic blood pressure by 5 mmHg, 5 more than the control. Additionally it was found to increase the compliance of the arteries during systole by 15%. Ejection fraction and cardiac output were unchanged however.  

This means in elderly humans ALT-711 does make changes but does not really improve heart function, It would be a good treatment for Diastolic Heart Failure, but not Systolic Heart Failure.


ALT-711 does not appear to decrease aging or symptoms of aging in adult humans.  Perhaps it will be a good second line or adjunct drug to Viagra and other phosphodiesterase inhibitors.


Nothing in this article or on this site should be considered medical advice or as an endorsement to violate any law of the country in which you reside.  The information given is for fun and entertainment purposes only.  All claims are 100% dependent upon proper diet and exercise.  Please consult a medical practitioner prior to any diet and exercise program.

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