• Pramipexole (Mirapex)

    Home Forums Chemically Correct Neuroscience/Nootropics Pramipexole (Mirapex)

    This topic contains 0 replies, has 1 voice, and was last updated by  Ex Dubio 3 months ago.

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    • #31561

      Ex Dubio
      Member
      #370512

      new_counter
      Member

      nice to know

      #370623

      Anonymous

      Prami lowers orexin neuron activation wich induces the sleepyness, 5ht1a antagonism counteracts some of this in rodents, so perhaps pindolol helps with the somnilence.

      #370798

      Anonymous

      [QUOTE=highchief;671337]Well, I had a run with pram…
      I started at 0.125 mg a day and titrated up to 1mg over the course of 2 weeks. Stayed at 1mg for 3 weeks, occasionally increasing to 1.5mg a day.
      Yesterday was last dose as I ran out and didn’t want to get more.
      No noticeable effects, nothing to make me want to continue using it.

      Initially a short boost in libido but then nothing. Some increasing OCD/compulsive behavior -which I’m diagnosed for- but nothing serious and nothing worse than before. I did notice though that I had less of an urge for sweets and pouch tobacco + other unnecessary stuff.
      I’d generally never been into sweets or tobacco/nicotine but lately had developed a craving for both, possibly due to overwhelming stress.

      I initially got prami to help with mood and depressive symptoms and to improve sexual health. I always get very worried if/when I’m not feeling well sexually.
      I also wanted to find out if I could take less dextroamphetamine (for ADD-PI) by using pramipexole. I did notice that I didn’t have as big an urge to take d-amp, but that could be because I started buspirone two weeks ago.
      Referring back to the sweets and nicotine cravings being less, I have a feeling that I had less of an urge for sex as well.

      I don’t know, seems my brain chemistry is weird and apparently that is the same with my endocrine system; lowering prolactin apparently doesn’t have a noticeable beneficial effect on me. I’ve in the past tried OTC methods for lowering prolactin, by B6 etc but never noticed anything positive.

      Would love to find a solution that works both my brain and for my body. So far d-amp works for my brain, at least most of the time, but not so well for my body.

      EDIT: so in total went on pramipexole for 5 weeks which in my understanding should be enough to see if it works.[/QUOTE]

      How is it going with buspirone? It made me far more interested in sex but I had erectile problems with it, so that scared me off. That was after 2 days (pathetic, I know). Perhaps the erectile problems don’t stick around with continued use? How do you find it?

      It is a weird one though, the 5HT1A receptor. It ignites sexually driven thoughts and yet induces penile inhibition, too. For men, it’s almost like a form of torture really. For women though, there are lots and lots of anecdotals, all across the internet of this drug making them HORNY. I guess they get the sexual interest but minus the ‘penis issue’, lol.

      #370801

      Anonymous

      [QUOTE=rjm07;671484]How is it going with buspirone? It made me far more interested in sex but I had erectile problems with it, so that scared me off. That was after 2 days (pathetic, I know). Perhaps the erectile problems don’t stick around with continued use? How do you find it?

      It is a weird one though, the 5HT1A receptor. It ignites sexually driven thoughts and yet induces penile inhibition, too. For men, it’s almost like a form of torture really. For women though, there are lots and lots of anecdotals, all across the internet of this drug making them HORNY. I guess they get the sexual interest but minus the ‘penis issue’, lol.[/QUOTE]

      Wow. Can’t really say.. I don’t think it has had an effect, but there are a lot of other external circumstances that have affected by sexual health.
      I’d say it might have, might, have helped a little bit by decreasing anxiety. But just a little bit. I actually noticed that my prescription wasn’t the full amount so I’ve been forced to take a smaller dose, which I believe hasn’t had much of an effect. Now I’m out of it for 1 more week until the doc’s appoinment so we’ll see if that has an effect.
      On a sidenote, I’ve added tribulus and Longjax from vitamin shoppe since a week ago, and l-tyrosine a few days back and noticed that my libido and erections are improving. But i’m also very irritable. I’m actually hoping its the frequent heavy weight training that is responsible for the improvements. I’ve been training regularly for the longest but with increased intensity and frequency for the past 3 weeks.

      I have to learn more about 5HT1A. Doesn’t sound too great with increased thoughts but penile inhibition!

      #370848

      Anonymous

      for some reason it seems like prami makes me feel sad and depressed, and I’m not really noticing any libido help from it. anyone else feel depressed from it?

      #370888

      Anonymous

      Nobody?

      #370915

      Idoruu
      Member

      [QUOTE=eternalsearch;670532]I’m experimenting sporadically with .25mg dosage, and wonder if there is an increased effectiveness in libido if you go to 0.5 mg for an acute experience?[/QUOTE]

      YMMV.

      Try it.

      Everyone is different.

      .5mg will probably make you a shoot your load across the room though and break a window or something, it might be too powerful.

      BTW, you’ve never had any chest/heart pains from prami at all?? I had to stop taking it because of that. =/

      #370986

      Anonymous

      Well, I had a run with pram…
      I started at 0.125 mg a day and titrated up to 1mg over the course of 2 weeks. Stayed at 1mg for 3 weeks, occasionally increasing to 1.5mg a day.
      Yesterday was last dose as I ran out and didn’t want to get more.
      No noticeable effects, nothing to make me want to continue using it.

      Initially a short boost in libido but then nothing. Some increasing OCD/compulsive behavior -which I’m diagnosed for- but nothing serious and nothing worse than before. I did notice though that I had less of an urge for sweets and pouch tobacco + other unnecessary stuff.
      I’d generally never been into sweets or tobacco/nicotine but lately had developed a craving for both, possibly due to overwhelming stress.

      I initially got prami to help with mood and depressive symptoms and to improve sexual health. I always get very worried if/when I’m not feeling well sexually.
      I also wanted to find out if I could take less dextroamphetamine (for ADD-PI) by using pramipexole. I did notice that I didn’t have as big an urge to take d-amp, but that could be because I started buspirone two weeks ago.
      Referring back to the sweets and nicotine cravings being less, I have a feeling that I had less of an urge for sex as well.

      I don’t know, seems my brain chemistry is weird and apparently that is the same with my endocrine system; lowering prolactin apparently doesn’t have a noticeable beneficial effect on me. I’ve in the past tried OTC methods for lowering prolactin, by B6 etc but never noticed anything positive.

      Would love to find a solution that works both my brain and for my body. So far d-amp works for my brain, at least most of the time, but not so well for my body.

      EDIT: so in total went on pramipexole for 5 weeks which in my understanding should be enough to see if it works.

      #371563

      Anonymous

      I’m experimenting sporadically with .25mg dosage, and wonder if there is an increased effectiveness in libido if you go to 0.5 mg for an acute experience?

      #371566

      Anonymous

      Same for me with cabergoline, same dosage, same question…

      #385988

      Idoruu
      Member

      [QUOTE=alias45;644799]This is great [LEFT][FONT=arial]news; rotigotine would be a safe alternative without this shit.[/FONT][/LEFT]
      [/QUOTE]

      What about Trivastal (purely for prolactin reducing sexual benefits)?????

      Would this work well?

      Also… any potential problems from Trivastal? (i.e heart)

      #386282

      Idoruu
      Member

      Anyone else get chest pains when on prami and taking ephedrine/other stims?

      #386283

      Idoruu
      Member

      [ATTACH=CONFIG]3868[/ATTACH][IMG]http://static.quickmeme.com/media/social/qm.gif[/IMG]

      #386297

      umair4site
      Member

      I’m sure you would…
      Agonist + “other-stims” = Catecholamine activation synergy

      #386298

      Anonymous

      A[FONT=arial]nythi[/FONT][FONT=arial]ng good for the extreme [/FONT][FONT=arial]nausia it ca[/FONT][FONT=arial]n cause?

      I wa[/FONT][FONT=arial]nt it with amphetami[/FONT][FONT=arial]ne a[/FONT][FONT=arial]nd viagra for a good fucksessio[/FONT][FONT=arial]n as it blocks the refractory period.[/FONT]

      #386299

      Idoruu
      Member

      [QUOTE=zodiac;644759]I’m sure you would…
      Agonist + “other-stims” = Catecholamine activation synergy[/QUOTE]

      Yeah… anyway to counteract this via dosing differently or dosing super low or something like [COLOR=#333333][FONT=Verdana]0.125 mg b.i.d? (i’m looking for hypersexuality only)
      [/FONT][/COLOR]
      I need my ephedrine :(

      What would I have to do in place of that?? Workout on no stims at all? I dunno if I can do that…

      Ex Dubio once mentioned that we can take .25mg-.5mg a day or the day of sex and have gr8 sex for 1-2 days (+pde5’s)

      But I think he later changed his stance on that…

      Perhaps I can play around with that I guess.

      Also, how long after I cease taking prami could I then go back to dosing ephedrine/stims like I used to? half-life is supposedly 8 hours but obviously it lingers a lot longer than that in the body, P.S I only started taking it like 3 hours ago.

      Surprised I have not seen the shooting Peter North loads with extreme velocity and intense orgasm side-effect mentioned yet btw.

      #386300

      Idoruu
      Member

      [QUOTE=alias45;644760]A[FONT=arial]nythi[/FONT][FONT=arial]ng good for the extreme [/FONT][FONT=arial]nausia it ca[/FONT][FONT=arial]n cause?

      I wa[/FONT][FONT=arial]nt it with amphetami[/FONT][FONT=arial]ne a[/FONT][FONT=arial]nd viagra for a good fucksessio[/FONT][FONT=arial]n as it blocks the refractory period.[/FONT][/QUOTE]

      Use a lower dose. What dosage did you try?

      #386319

      Idoruu
      Member

      UH OH!!!

      Pramipexole (Mirapex) Associated With High Risk of Heart Failure

      [URL]http://medicalopedia.org/2707/pramipexole-mirapex-associated-with-high-risk-of-heart-failure/[/URL]

      MORE..

      http://www.ncbi.nlm.nih.gov/pubmed/22109939

      The use of dopamine agonists, especially pramipexole and cabergoline, is associated with an increased risk of heart failure.

      FUCK OFF..

      #386323

      Anonymous

      [QUOTE=Ubiyca;644784]UH OH!!!

      Pramipexole (Mirapex) Associated With High Risk of Heart Failure

      [URL]http://medicalopedia.org/2707/pramipexole-mirapex-associated-with-high-risk-of-heart-failure/[/URL]

      MORE..

      [URL]http://www.ncbi.nlm.nih.gov/pubmed/22109939[/URL]

      The use of dopamine agonists, especially pramipexole and cabergoline, is associated with an increased risk of heart failure.

      FUCK OFF..[/QUOTE]
      O[FONT=arial]n first gla[/FONT][FONT=arial]nce i thi[/FONT][FONT=arial]nk just i[/FONT][FONT=arial]ncreases the risk of hearth trouble with lo[/FONT][FONT=arial]ng term use a[/FONT][FONT=arial]nd [/FONT][FONT=arial]not that it somehow weake[/FONT][FONT=arial]ns the heart so a stim ca[/FONT][FONT=arial]n cause trouble right away; i thi[/FONT][FONT=arial]nk fucki[/FONT][FONT=arial]ng for hours o[/FONT][FONT=arial]n speed should still be ok to do (atleast i hope so) ill research it.

      I have[/FONT][FONT=arial]nt tried it yet; tought a[/FONT][FONT=arial]ny dose cause [/FONT][FONT=arial]nausia a[/FONT][FONT=arial]nd you [/FONT][FONT=arial]needed to get slowly tolera[/FONT][FONT=arial]nt to it.

      This stuff looks [/FONT][FONT=arial]next to amphetami[/FONT][FONT=arial]ne a[/FONT][FONT=arial]nd viagra as the best sexdrug ever; forgot about it.[/FONT]

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