Vanadyl Sulfate is a form of vanadium that is often used to speed glucose clearance after a carbohydrate containing meal. Doing so is believed to increase glucose storage in muscle tissue, improving body composition and athletic performance. A study published in the Journal of Clinical Endocrinology and Metabolism examined the effects of high dose vanadyl sulfate on type 2 diabetics.
11 Type 2 diabetic subjects were given 150 mg per day of vanadyl sulfate for a period of 6 weeks. As expected, the supplementation increased glucose clearance from the blood. Something interesting that the researchers took note of was that the lowered blood glucose did not correlate in the way they expected with glocuse clearance as a result of insulin. Vanadyl sulfate improved insulin sensitivity in both muscle and liver, but it was concluded that the main target for improved insulin sensitivity was the liver.
Preferably, the vanadyl sulfate would have targeted skeletal muscle for improved insulin sensitivity, as this would ellicit the greatest improvement in body composition. The dose used in the study, however, was extremely high. The results observed in the study may not be the same as those observed at a more moderate dose. If the results seen here hold true to what is seen with lower dosages, than there may be better options available for increasing glycogen storage than vanadyl sulfate.
Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, & Redondo JC. (2001). Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 86(3), 1410-7.
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