Every so often, as our understanding of human health and the body’s needs evolves and improves, we gain new perspective on a natural compound’s unusually exceptional benefits to the wellness of those who consume it. If the body is a temple, as that ancient adage tells us, then compounds like the omega-3 fatty acids found in fish oil and the polyphenols and catechins contained in green tea can be considered the pillars that support and strengthen it throughout the years, that lend it beauty and hold it aloft even in the face of external and internal stressors. Today, we are here to induct a new member into this highest echelon of nature’s miracle health-providers: SesaThin™, a product which promotes fat-loss and powerfully lowers cholesterol and blood triglycerides, while also providing potent anti-oxidant and anti-inflammatory protection to its users. So follow along, as we detail the intricacies of nature’s wondrous leanness and longevity lignan(s)—SesaThin™.
Super Fish Oil?
The active ingredient in SesaThin is sesamin(/episesamin), a naturally-occurring sesame lignan that’s effects on lipid metabolism represent a virtual metabolic dream come true. Although not a fatty-acid like the omega-3s in fish oil, sesamin acts just like certain fish fats as a ligand for PPARalpha (peroxisome proliferator receptor alpha), a type of ligand-activated transcription factor in human cells which plays an important role in fat-metabolism (1,2,3), fat-storage (1,2,3), glucose homeostasis (3), and inflammation (3,4). In fact, studies have shown that sesamin elevates fatty acid oxidation as much as 10-fold over normal levels via PPAR-alpha activation that is significantly more potent than what can be attained with fish oil (5,6,7). Obviously, it goes without saying that SesaThin’s ability to increase fatty acid utilization while suppressing fat-storage (1,7,8,9) carries a host of benefits, not the least of which is a significant correlation between leanness, PPARalpha expression, and improved long-term health (3,5,10,11,12).
SesaThin: The Key to Overall Metabolic Well-Being
Truly, SesaThin’s effects on fatty acid metabolism are nothing less than remarkable. Nonetheless, to say SesaThin is ‘just a fat burner’ is akin to calling filet mignon ‘just beef.’ No, SesaThin’s metabolic effects are diverse and far-reaching, and show promise combating everything from Metabolic Syndrome (Syndrome X) to atherosclerosis to high cholesterol (3,4,11,12,13,14,15,16,17).
For one, SesaThin’s ability to reduce lipid synthesis will help to maintain or even heighten high leptin and insulin sensitivity (13,14), even during periods of carbohydrate consumption (18). This will directly improve your body’s ability to send nutrients to the right places like the brain and skeletal muscle for cellular energy demands, while antagonizing the potential for insulin resistance and adipose (fat) storage. After all, fibrates, a class of hypolipidemic drugs which act as PPARalpha agonists just like SesaThin have been found to significantly improve serum glucose, insulin, and leptin levels caused by diet-induced obesity (19). They have also been demonstrated to dramatically improve insulin sensitivity and the diabetic condition of MKR mice, which have a mutation in the IGF-1 receptor, rendering them Type II diabetic (20).
Today, in our modern era of convenience stores and super-sized value meals—factors which tend to leave the average Western diet rife with high-insulemic, calorie-dense foods that overstuff cells and maul insulin sensitivity—SesaThin’s effects in this regard are most welcome. If we backtrack momentarily to reconsider Type II diabetes, a condition which is strongly correlated to insulin resistance and obesity (and also now represents 5% of the United States population (21)), one starts to see that SesaThin is not just a novelty for gym-goers and health-nuts—it should be considered a staple supplement for anyone seeking health and physical well-being well into old age.
Wait, it Gets Better?
In a study on oxidative stress published in 2001 in the journal Pharmacological Review (22), the study’s researchers note quite presciently that, at the time, “a vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as mediators of inflammation, shock, and ischemia/reperfusion injury.” Since then, our fledgling understanding of anti-oxidant/oxidant status, or REDOX, in the human body has improved to the point where researchers point to an ‘optimal balance’ of ROS (reactive oxidant species) and anti-oxidants as key components in guarding the body against the ill effects of lipid peroxidation, protein oxidation, cell-damage or apoptosis, and a host of other age, disease, or injury-related conditions (23).
So how does SesaThin figure into all of this? Well, given what we know thus far about the wondrous anti-oxidant and anti-inflammatory properties of SesaThin, it is not hard to speculate that its principal actives (the lignans sesamin and episesamin) will go a long way in helping one maintain that ever-so-crucial ‘optimal balance’ in REDOX function. For one, SesaThin’s ingredients have been shown to suppress excess superoxide formation and hypertension in stressed animal models (24,25) by protecting and maintaining proper function of endothelial elements like nitric oxide (NO) (26 ). This lead scientists to conclude that the “antioxidative propert[ies] of sesamin may apply to the prevention of oxidative stress-related diseases, such as diabetes, hypercholesterolemia, and atherosclerosis” (24).
Additionally, sesamin has been shown to decrease lipid peroxidation in response to fish oil consumption (perhaps the only negative result of fish oil supplementation we know of), while increasing serum vitamin E levels and preventing its metabolism (27,28). Furthermore, studies show that vitamin E and sesamin work in synergy when combined to reduce systemic oxidative stress (28,29). But SesaThin doesn’t just stop with free radicals—it also provides anti-oxidant protection against oxidative-stress prompted by everything from exercise (30) and alcohol (31) to high-sodium diets (28), which, given our society’s present love of processing and preserving foods, probably includes yours’ and that of just about everyone you know. Other evidence suggests that it may help significantly in maintaining healthy blood-pressure levels as well (32).
If one looks at SesaThin’s ability to positively modulate cholesterol, the picture looks even brighter. First and foremost, SesaThin markedly decreases triglyceride (TG) formation and increases TG uptake and fatty acid oxidation (5,9), while decreasing cholesterol levels (16,17,33). And be prepared to cue the “you gotta’ be kidding me’s”, because it’s actually a little better than that. SesaThin seems to actually increase HDL cholesterol (the good stuff), while putting your LDL (the bad stuff) to bed without its toys (16,17,33).
In fact, just 100mg per day of SesaThin (1/15th of a regular daily dosing of SesaThin) has been clinically demonstrated to be modestly, but significantly hypocholestemic in humans (34). Morever, SesaThin also antagonizes inflammation (10,12,35), both in the liver and through the body, particularly through its ability to suppress the notorious anti-inflammatory prostaglandin PGE2 (35). Thus, in addition to being greatly beneficial for general health, these factors make SesaThin a must-use for those with certain lifestyles – particularly thos with high stress, anabolic steroid users, or regular stimulant or alcohol (ab)users.
- Increases fat burning
- Decreases fat storage
- Protects against obesity and obesity-related conditions
- Combats elevated cholesterol
- Is a potent anti-oxidant
- Is a potent anti-inflammatory
- Is hepato(liver)-protective
- Is stimulant Free
So, for your physique and your health, we proudly bring you SesaThin™.
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