Fat Loss: Pyruvate is a metabolic intermediate known as a ketone. Ketones are used as energy sources by the body when the body is in ketosis. Two molecules of pyruvate are formed from glucose during the process of glycolysis, which creates energy in the form of ATP. This pathway is reversible and the molecule can be converted back into glucose or fatty acids or converted into the amino acid alanine. It can also be used to generate energy in the citric acid cycle. You might wonder why, if it is made from glucose, would you need to take it in supplemental form? The answer is that has been shown in studies to increase fat loss in those who are on a reduced calorie diet. The reason may be that it acts as a satiety signal in the brain to reduce levels of a molecule called AGRP. AGRP stimulates appetite in the brain. Pyruvate may also increase endurance by acting as an energy substrate during prolonged bouts of exercise.