Prohormones: 11-Oxo (TM)
Adrenosterone is a relatively new prohormone that does not fall under the 2004 legislation. This prohormone is the 11-keto substituted version of androstenedione. There is not much data on this prohormone but it is produced naturally in humans. Presumably, some portion is converted to 11-ketotestosterone which has some degree of androgen receptor binding. Another proposed mechanism of action for this prohormone is the inhibition of 11-beta hydroxysteroid dehydrogenase type 1. Adrenosterone inhibits this enzyme selectively over the type 2 enzyme and prevents the conversion of inactive cortisol metabolites to active cortisol. This results in an anticatabolic activity and supposedly makes this prohormone effective in a cutting stack. Anecdotal reports show this prohormone to be very mild with higher doses needed to elicit a response. The anabolic to androgenic ratio for this prohormone bears this out. One test shows it to have 70% of the anabolic activity of testosterone with half of the androgenic activity while another study shows it to have only 10% of the anabolic activity.