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guy curling huge dumbbellsPhosphatidylserine is often used to revent excess cortisol, especially during and after exercise, and is also used for its cognitive benefits. Can phosphatidylserine enhance athletic performance too? A study published in Medicine and Science in Sports and Exercise shows that this may be the case.

16 fit male subjects completed an exercise session simulating a soccer game followed by a run to exhaustion. Beginning 4 days after the exercise session, the subjects began consuming either 750 mg of phosphatidylserine daily or a placebo. The subjects consumed the supplement for 10 days, and then completed the same exercise session again.

Contrary to other research, the cortisol response to exercise was unaltered by phosphatidylserine. The results also showed no difference in soreness or oxidative damage. What was interesting was that phosphatidylserine increased how long the subjects were able to run before becoming exhausted. These results show a potential ergogenic benefit of phosphatidylserine, although by an unknown mechanism as there was no difference in the areas in which the researchers expected to see a change.



Kingsley MI, Wadsworth D, Kilduff LP, McEneny J, & Benton D. (2005). Effects of phosphatidylserine on oxidative stress following intermittent running. Medicine and Science in Sports and Exercise. 37(8), 1300-6.

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