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Muscled guy smilingPhosphatidylserine is often used to improve cognitive function, decrease depression, an it is also thought to prevent excessive cortisol levels. A study published in the Journal of the International Society of Sports Nutrition demonstrates the effects of phosphatidylserine on the cortisol response to exercise.

In the study, 10 healthy male subjects took either 600mg phosphatidylserine or a placebo daily for a period of 10 days. After 10 days of supplementation, the subjects performed a 15 minute moderate intensity exercise bout intended to stimulate a rise in cortisol levels. The subjects that supplemented with phosphatidylserine showed a lower peak cortisol concentration in response to the exercise and also an improved testosterone to cortisol ratio over the placebo group. Levels of lactate and growth hormone were also monitored, but no changes were observed between the two groups.

These results deomonstrate that a moderate dose of phosphatidylserine does in fact prevent the exercise induced rise in cortisol levels. This makes phosphatidylserine of particular benefit to those who exercise for long periods of time to prevent muscle breakdown as a result of excessive cortisol. Phosphatidylserine may also be of benefit to those doing large amounts of cardiovascular exercise in an attempt to lose body fat to attentuate the excessive level of cortisol that often comes with this making it difficult to lose body fat.



Starks MA, Starks SL, Kingsley M, Purpura M, & Jager R. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition. 5, 11.

ABOUT THE AUTHOR: Cassie is a chemistry major and national level bodybuilder. Questions or comments? Talk to Cassie on the FORUM or on FACEBOOK.

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