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Peptide Hormones: CJC-1295

CJC-1295 is a derivative of human GH-releasing factor1-29(HGRF1-29). HGRF1-29 is a naturally occurring peptide that is actually a truncated form of a larger peptide that binds to the growth hormone secretagogue receptor (GHS-R) and causes the release of growth hormone. CJC-1295 has four amino acids substituted in its chain that result in strong binding to serum albumin and prolong its half-life in the body. A single subcutaneous (sc) injection results in measurable quantities of CJC-1295 in the blood for up to 13 days. Additionally, a single dose of 60 ug/kg of CJC-1295 results in elevated levels of growth hormone (125%) while the pulsatile secretion of GH is maintained. Furthermore, 60 ug/kg of CJC-1295 elevated IGF-1 levels to the upper limit of normal. A dose of 30 ug/kg of CJC-1295 given weekly maintained its response with no evidence of desensitization.

CJC-1295 is available on the black market and is currently being utilized by bodybuilders. A dose of 30 ug/kg equates to 3 mg per week for a 100 kg (220 lb) man and of course this would be doubled for a dose of 60 ug/kg. At these doses it may be cost prohibitive. Some are injecting CJC-1295 daily or even multiple times per day. There may be a danger of desensitization with frequent dosing. Many report seeing little gain with CJC-1295. This may be due to the fact that increasing plasma IGF-1 does not necessarily correlate with increased muscle mass due to changes in IGF binding proteins that may reduce the muscle-building activity of IGF-1. The “lack” of gains may also be due to users expecting AAS-like gains. Since CJC-1295 does not load water but results in lean gains as well as fat loss, large increases in scale weight should not be expected.

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