Peptide Hormones: GHRP-6 is a synthetic growth hormone releasing peptide that is only 6 amino acids in length. There is some evidence that GHRP-6 may work through a different pathway than stimulation of GHS-R. One researcher has proposed that GHRP-6 acts as a functional antagonist of somatostatin. GHRP-6 has some oral bioavailability but the doses required (300 ug/kg) make this route extremely expensive. Given subcutaneously, the dose would fall closer to the intravenous dose of 1 ug/kg with most people using about 2 or 3 ug/kg per day. One of the draw backs to the use of GHRP-6 is its short half-life or about 20 minutes. Most users will take GHRP-6 just before bed or even multiple times per day. It has been shown in the literature that GHRP-6 taken together with insulin resulted in a larger GH release than either drug taken alone. GHRP-6 has also been shown to be synergistic when combined with human growth hormone releasing hormone. This has led some to use GHRP-6 in combination with CJC-1295.