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By Chris Clancey

Author’s note: this article will be somewhat of a departure from normal M&M protocol in that much of what will be presented and discussed below is based strictly on conjecture, and reflects at best only a very limited understanding of the full pharmacological effects of Ergopharm’s AMP. However, we at M&M feel that the subjective experiences and feedback from numerous stackers, our detailed knowledge of H.E.A.T.’s workings, a small amount of disclosure surrounding ‘geranamine’, and our familiarity with other stimulants which have been researched extensively by the scientific community, gives us just enough to comfortably go out on a limb with this one. Consider yourself warned.
Like most, I’m a big fan of positive synergy. Getting more bang for your perennial buck, the biggest return on your investment, reaping the genuinely memorable yields—there’s just so much to love about a singular ‘sum of parts’ that leaves the most lasting of impressions when you’re fortunate enough to experience its magnificence under those ‘just-right’ conditions.

For us fitness enthusiasts, more often than not, it’s the workout that defines our days and offers us that portal which enables us to temporarily transcend the mundane and just feel free, complete, and altogether comfortable with ourselves and our state of being. Chances are—if you’re anything like me—you can recollect your past “perfect workouts” better than you keep track of your friend’s birthdays. And so what if you only vaguely recall your first kiss but can wax Joycean in the locker-room for hours about the time you front-squatted ‘til you puked? You know full well you tied the knot with gym-going well before you ever even considered settling down with your ‘other better half.’

And that’s what this article is all about—our desire to share with you the miracle pairing that may very well fan the flame between you and the iron to an all new level: the ErgoLean AMP™-Avant Labs H.E.A.T. ™-stack. A taste of stimulant synergy that not only rocks the socks off ephedrine and caffeine, delivers indomitable workout performances with the consistency of tax day, and assaults appetite with a “one shot, one kill” mentality, but heck, even has Par Deus back exercising again.

The Recipe and the Theory

Geranamine™, the corner-stone active in AMP, is a naturally occurring adrenaline-like stimulant that makes one fast forget about ephedrine when combined with a catecholamine-potentiating substance like caffeine. Yeah, it’s that good. According to Patrick Arnold, the researcher who discovered ‘geranamine’, there is as-of-yet undisclosed research that suggests the compound is a potent inhibitor of norepinephrine (NE) uptake centrally in the brain, which would deprive the brain of its basic negative-feedback mechanism for regulating/curtailing NE release.

And while I can’t cite (much less see) this data, believe you me when I say I buy it wholly and completely. In fact, based on my own personal experiences with stimulants, amphetamines, and psychotropics, I’m willing to speculate that the energized ‘AMP-euphoria’ that so many users have reported represents a cocktail of heightened NE release and uptake inhibition, coupled with increases—and possibly additional uptake inhibition—of serotonin (5-HT) and dopamine (DA). Or rather, just consider the fact that an elevated cortisol/stress (re: exercise & NE) response in conjunction with elevated 5-HT signaling in the amygdala is highly associated with dominant, energized, and hypervigilant states in adult humans (1,2,3,4). Sounds a little like AMP, now doesn’t it?

Others with a great deal of knowledge and familiarity with psychotropics have also ventured similar speculation. So while the exact details of AMP’s pharmacology remain unclear, we can venture with a great deal of certainty that AMP acts on stress and pleasure neurotransmitters in a manner similar to ephedrine and caffeine, but with greater serotonigenic/dopaminergic and noradrenergic-uptake-blocking components.

So where does our own H.E.A.T. stack™ factor into this equation? Simple: we include it to provide a one-two synergy punch that not only heightens the neurotransmitter effects-profile of AMP, but also stimulates additional mood and repartitioning pathways, both centrally and peripherally. Ultimately, it ends up looking a little like this:

Hordenine:

inhibitor of NE uptake, just like geranamine (and tyramine as well), allowing for further maintenance of exercise-level neurotransmitter activity. Hordenine is also a selective MAO-B inhibitor, rendering it capable of so it will preferentially increase dopamine through this pathway (5,6). Not only that, hordenine-inhibition of MAO-B also renders a much greater portion of the phenylethylamine (PEA) content in AMP’s chocamine orally bioavailable. PEA, a naturally occurring neuro-stimulant similar in many ways to amphetamine, is normally rapidly metabolized by MAO-B, and rendered null as a stimulant. With the HEAT/AMP stack, we bypass this bioavailability issue, and enable a much greater yield of active, stimulatory PEA (7).

Eviodamine:

enhances the thermogenic/lipolytic effect of AMP (8), and is also a vasodialator, which will help to counteract some of the AMP-induced vasoconstriction and lower blood pressure (8,9). Thirdly, since eviodamine has been shown to inhibit gastric emptying and increase plasma CCK, it’s hardly a stretch to mention this as just one more dynamic that enables the AMP/HEAT stack to show all the pretenders out there the true meaning of ‘appetite-suppression’ (10).

Alpha-Y™:

an alpha-2c adrenoreceptor antagonist (11), Alpha-Y™ will inhibit DA negative feedback and increase central dopaminergic tone—which is already going to be elevated from the caffeine/chocamine, tyramine, MAO-B inhibition of hordenine, and potentially geranamine™ as well (12,13). The result is a significant shift in the mood-inducing neurotransmitter effects of the stack to favor energy and euphoria, rather than stress and ‘tweak.’ Moreover, modest disclosure from Ergopharm has made it known that geranamine acts in an adrenal stimulant fashion, and, unlike other yohimbine analogues, Alpha- Y™ is a negative feedback-blocker of norepinephrine’s big-time catecholamine cousin epinephrine (adrenaline) (14), thereby making the AMP/HEAT stack a true surge of NE, adrenaline, & DA, which some possible other neurotransmitter ‘goodies’ to boot.

Tyramine:

stimulates NE release (15) and, perhaps even better when we consider the NE uptake-inhibiting properties of geranamine, prevents it from being metabolized by inhibiting MAO-A (16). Also preferentially increases DA via three mechanisms: 1. direct conversion by the enzyme CYP-2D6, 2. a decrease in DA metabolism as a result of its MAO-inhibiting effects, and 3. it’s ability to strongly inhibit DA uptake—IC50 in the nanomolar range (16,17)

The result is an inferno tag-team guaranteed to spark cognition into the stratosphere and ignite motivation to white-hot levels. The fact that the AMP/H.E.A.T. stack will also act synergistically to improve mood, potently bury appetite, and strongly stimulate lipolysis ‘taint terribly shabby either, while we’re on the subject.

Now We’re Cookin’ with Catecholamines

I must say, I truly do pity the scant few AMP-nonresponders out there, because this stack puts an ‘S’ on my chest in the gym, workout after workout, without fail. Think I’m hyping you? Then listen to some assorted feedback from others who’ve dabbled in this Molitov cocktail of a stimulant stack. When asked to evaluate AMP/H.E.A.T. at different doses, one tester reported that three H.E.A.T. and two AMP produced mood-enhancing effects “much more pronounced than AMP [or H.E.A.T.] alone”). When he bumped the dosage up to six capsules of H.E.A.T. and four capsules of AMP, he responded enthusiastically that he blew through a double full-body depletion workout in a single session with “so much energy… the whole workout flew by. I actually enjoyed it.” People—that just doesn’t happen. Anyone who’s ever immersed themselves in the draconian squalor of high-rep, lactic-acid-threshold depletion strength-training knows that ‘flew by’ and ‘enjoyment’ are about as appropriate for characterizing those sorts of grueling workouts as ‘rather mild’ would be for describing this year’s hurricane season.

On neither side of that analogy is there a pun.

Another user—an individual not much for waxing poetic during his supplement reviews—broke it down and got right to the point (after taking 3 capsules of H.E.A.T. and 4 capsules of AMP) by saying: “holy sh*t it was awesome… the energy was amazing—a beautiful synergy between AMP and HEAT for sure.” Needless to say, the AMP/H.E.A.T. stack has definitely been christening a few believers of late. “Oh my holy God, the [central nervous system] stimulation is f’n unreal,” reports a third tester; “methinks this is definitely far superior [to] ephedrine/caffeine.” Only ‘definitely superior’ to that stimulatory slouch ephedrine and caffeine; hmm *pun alert*, perchance we should go back to the drawing board…

No, the bottom line is the H.E.A.T./AMP stack has redefined stimulant synergy, and ushered in a new era in pre-workout energizers. It is a combination that has made us see the value in sometimes setting aside competing business interests when a certain fit enables two separate companies’ products to unite in the name of owning some imitators.

As always, leading the way in performance-enhancement innovation stand Avant Labs, Ergopharm, and the AMP/H.E.A.T. Stack, the new-jack stim-stack that will have you seeing fireworks well beyond the Fourth of July. Remember to always assess your tolerance to each supplement separately, and to combine both with caution and care. Cheers all, and ‘happy blast-off’.

ErgoLean AMP™ and geranamine™ are both trademarks of Ergopharm/Proviant Tech., all rights reserved.

References

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3. Gallagher P et. al. Effects of acute tryptophan depletion on executive function in healthy male volunteers. BMC Psychiatry. 2003; 3: 10.

4. Meneses A. 5-HT system and cognition. Neurosci Biobehav Rev. 1999;23:1111–25.

5. Barwell C et al. Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. J Pharm Pharmacol. 1989 Jun;41(6):421-3.

6. Palfreyman F et al. Design and early clinical evaluation of selective inhibitors of monoamine oxidase. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):967-87.

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8. Kobyashi Y et al. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001 Oct;67(7):628-33.

9. Hu C et al. The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin gene-related peptide. Planta Med. 2003 Feb;69(2):125-9.

10. Wu C.L. et al. Effects of evodiamine on gastrointestinal motility in male rats.
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11. Virolainen S et al. ssessment of alpha2-adrenoceptor antagonist potency with GTPase assay. Eur J Pharmacol. 1997 Nov 12;338(3):293-6.

12. Brede M et al. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol Endocrinol. 2003 Aug;17(8):1640-6. Epub 2003 May 22.

13. Sallinen J et al. D-amphetamine and L-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the alpha2C-adrenergic receptor subtype. Neuroscience. 1998 Oct;86(3):959-65.

14. Seig A et al. Epinephrine-induced hyperpolarization of islet cells without KATP channels. Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E463-71. Epub 2003 Nov 12.

15. Scriven A et al. Changes in blood pressure and plasma catecholamines caused by tyramine and cold exposure. J Cardiovasc Pharmacol. 1984 Sep-Oct;6(5):954-60.

16. Finberg J et al. Relationship between tyramine potentiation and selective inhibition of monoamine oxidase types A and B in the rat vas deferens. Br J Pharmacol. 1982 Sep;77(1):13-21.

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