Fat Loss: Meridia, generic name sibutramine, is an oral weight loss aid that is structurally related to amphetamine but acts as a serotonin-norepinephrine reuptake inhibitor, much like several antidepressant medications. Sibutramine is scheduled as a class IV drug and is therefore a controlled substance. The abuse potential is considered to be very low. Sibutramine has several side effects associated with its use, uncluding high blood pressure and cardiac arrhythmias. The use of Meridia results in only modest weight loss of 9 to 18 pounds over a one year period.