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Growth Hormone Secretagogues are peptide hormones

Growth Hormone Secretagogues are peptide hormones

What is Growth Hormone

Growth Hormone (GH) is an important hormone that is used for fat loss, increase healing, and to slow the aging process. But this article isnt about the use of hGH. This article is about how to cause natural GH to be released. I covered all the parameters of how natural GH induction is superior in my GHRP-6 and CJC-1295 articles. Simply put, its better to have the real thing.
GH is released from the pituitary after Growth Hormone Releasing Hormone (GHRH) binds to its receptor. Another GH releasing receptor is present however, the ghrelin receptor. This of course binds ghrelin. The Growth Hormone Secretagogues are peptides synthesized to bind to these 2 receptors.

The important thing to understand is this: The 2 receptors when bound release way way more growth hormone than if you had one or neither. If exercise released 2 units and sleep 3, then with either a GHRH or GHRP then you might have levels of 5 and 7 respectively. But both! More like 13 and 16.


All the Growth Hormone Secretagogues are dosed at 1 mcg/kg. Most people divide 100mcg up over multiple shots per day. Your pituitary is ready for another burst of GH every 3 hours. If carbs are present in your body this pulse is severely diminished. Thus for maximal effect of fat loss in a zero carb state use both a GHRP and a GHRH at 3 hour increments, with total daily dosage at no more than 100 mcg a day each, 50 for a woman. Augmenting thyroid function with T2 would amplify this fat loss.

To amplify muscle growth post workout stack your GHRP and GHRH with MGF or IGF-1 LR3 along with a sublingual prohormone like 1-Andro before you begin to consume your first carbs of the day (30 minutes post workout). This will result in the biggest post workout GH spike. After 30 minutes post workout the GH window is closed but the glut-4 window is open. This is when you consume carbs and amino acids specifically leucine.
The IGF-1 will shuttle the carbs and amino acids into the muscle and the MGF and the 1-andro signal the muscle to use those building blocks to grow new muscle. Why do we need GH for this? GH is the mediator for the IGF-1Ea synthesis in the liver, it also protects your muscles from the cortisol while you wait to have your carbs.

But I’m Scared of Needles!

If you don’t want to be injecting a semi-legal substance which is not intended for human use I have an alternative, Wyked 2.1. I designed this pre workout to have an oral GHRP and GHRH analogues which will amplify pre workout growth hormone. There are a ton of other reasons to use it, so click on the link. Stacking T2 with Wyked 2.1 amplifies the fat burning effect greatly, and both work best in a carb free state pre workout. Rise and Swell which is my morning testosterone booster Also has the same GHRH and GHRP promoting benefits of Wyked 2.1.  Additionally if you just want the benefits of a sublingual spray of potent GHRH and GHRP analogs check out GHenerate! This sublingal spray will get you the results of the semi-legal injectables.


Below is a list of synthetic ghrelin analogues, aka GHRPs.

  • Hexarelin, GHRP – 6, MK-677, Ipamorelin, and GHRP-2 are interchangeable as they all bind the the ghrelin receptor and stimulate GH release.
  • Hexerelin is the strongest but has The side effects of prolactin and increase
  • GHRP-6 is the next strongest but does not have cortisol and prolactin increase in doses under 100 mcg. It does however induce hunger like ghrelin does.
  • GHRP-2 is the least strong but has no hunger side effect, and moderate prolactin and cortisol release.
  • Ipamorelin is as strong as ghrp 6 and has no prolactin or cortisol effects, yet is not popular.
  • MK-677 is like an oral Ipamorelin which has a 25 mg dose (the only exception because its oral).
  • Other research compounds are under development by pfizer and other companies by the names Capromorelin, Tabimorelin, (SM-130,686)


Below is a list from the least complicated to most complicated Growth Hormone Releasing Hormones.

  • GRF(1-29): Aka Sermorelin
    Generation: Original analog of GHRH
    Changes: Since no amino acid changes were made and with no DAC protection it had a half life less than a minute.
  • CJC-1288 with DAC:
    Generation: First gen DAC attached to GRF (1-29)
    Changes: Since no amino acid changes were made it had a half life of minutes.
  • CJC-1293 with DAC:
    Generation: Second gen DAC attached to GRF (1-29)
    Changes: One amino acid change it had a half life of 5 or so minutes.
  • CJC-1293 without DAC:
    Generation: In between 1st and 2nd (1.5 gen)
    Changes: One amino acid change which made it a bit longer lasting than original GRF(1-29) but without DAC had less protection so it had a half life just under 5 minutes.
  • CJC-1295 with DAC:
    Generation: Third gen DAC attached to GRF (1-29)
    Changes: Four amino acid changes which made it last much much longer than original GRF(1-29). It had a half life of around a week.
    *One problem with such a long half life is GH bleed, you don’t want to use this long term.
  • CJC-1295 without DAC: Aka Tetra-substituted, Aka Modified modGRF (1-29)
    Generation: Tetra-substituted GRF (1-29) same as third gen but with no DAC attached.
    Changes: Four amino acid changes which made it last much longer than original GRF(1-29). It had a half life a little over 30mins.

So as you can see the CJC-1295 without DAC has the best half life of 30 minutes since a week is too long the CJC-1295 with DAC is out.

Nothing in this article or on this site should be considered medical advice or as an endorsement to violate any law of the country in which you reside. The information given is for fun and entertainment purposes only. All claims are 100% dependent upon proper diet and exercise. Please consult a medical practitioner prior to any diet and exercise program.