This is the first, and certainly not the last, product released by the super couple Rob and Dana Linn Bailey, If you don’t know who they are you’re probably on the wrong web site, Dana is the largest name in the IFBB and easily the most popular Physique athlete in the world, more popular than […]

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In the last article, we covered the research on the neuroprotective and memory-improving capabilities of vinpocetine. We found that vinpocetine has neuroprotective effects in many situations, and there are studies providing evidence that it has utility as a nootropic in humans. We are now going to discuss the mechanisms through which vinpocetine leads to these beneficial effects.

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You did it. You told yourself you weren’t going to, but you did it. I even explicitly told you not you, but “screw me,” you did it anyways. You cashed the paycheck, told the spouse you were heading out because they were having a “2-for-1” sale on sweet potatoes at the local grocer, and instead went and paid a trip to Chino the back-alley Pergolide dealer. After all, you told yourself, the weather is getting warmer, and I should be out and about in it, showing up all my buddies with some new freaky striations on my left latissimus dorsi.

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After piracetam, vinpocetine (ethyl-apovincaminate, 14,-ethoxycarbonyl-(3alpha, 16alpha-ethyl)-14, 15-eburnamine) is perhaps the most well-known nootropic and is regarded by some as more important [1]. First synthesized about forty years ago, vinpocetine is a derivative of vincamine, which is found in the periwinkle plant (Vinca minor). Other compounds in the vinca alkaloid family include vinburnine, vintoperol and brovincane [2]. After being synthesized in Hungary, the neuroprotective and nootropic properties of vinpocetine were discovered, and appeared under the name Cavinton in 1978.

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We have previously discussed the properties of the prototypical nootropic drug, piracetam. Piracetam improves learning and memory and provides neuroprotection in a number of experimental models, and also appears to improve learning and memory in healthy humans, all the while being devoid of side effects and toxicity. Although the mechanism of action is not well established, there is evidence for the involvement of the glutamatergic and cholinergic systems.

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