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Body Builder PosingSteroids: Stenbolone is very similar to both dromostanolone and oxymetholone. It is a derivative of DHT with a double bond between carbon 1 and 2 and a methyl group at position 2. The methyl group at position 2 protects the molecule from both aromatization to estrogen and to some degree, inactivation in muscle tissue by 3-alpha hydroxysteroid dehydrogenase. This 2-methyl group does decrease binding to the androgen receptor somewhat. This makes for a molecule that has slightly less binding affinity for the androgen receptor than primobolan but like primobolan, this steroid cannot be converted to estrogenic metabolites through aromatization. Stenbolone is considered by some to be a gentler version of oxymetholone. This steroid has a similar structure to oxymetholone but is not C-17 alpha alkylated so it has minimal effects on liver function. Stenbolone builds up red blood cells like oxymetholone and is metabolized to some degree to dromostanolone which has also been shown to increase red blood cells1,2.

Stenbolone does not seem to result in as much size gain as anadrol or as much bloat so it likely does not have as much inhibitory activity on 11-beta hydroxylase. Stenbolone tended to be injected daily because of the short half-life of the acetate ester. Additionally, the acetate ester seems to produce pain and swelling at the injection site. Stenbolone has similar androgenic activity compared to 1-testosterone, the unmethylated version of this drug, but with higher anabolic activity. This is likely due to the reduced conversion to 3-alpha hydroxy metabolites. Stenbolone offers many of the advantages of oxymetholone with less bloating and elevated blood pressure.

 

1. Schanzer W: Metabolism of anabolic androgenic steroids. Clin Chem. Jul;42(7):1001-20, 1996

2. Sanchez-Medal L, Gomez-Leal A, Duarte L, Guadalupe Rico M. Anabolic androgenic steroids in the treatment of acquired aplastic anemia. Blood. 34(3):283-300, 1969

Adapted with permission from Seth Robert’s Anabolic Pharmacology, all rights reserved.

Steroids: Stenbolone


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