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Steroids: Cheque Drops Mibolerone

Cheque drops, containing the steroid mibolerone, were originally produced as an aid in keeping female dogs from going into heat. Technically it is considered and androgen, however, mibolerone is also very progestational which is the mechanism for its effects in female dogs1. In fact, mibolerone has about twice the affinity for the progesterone receptor as progesterone itself. This drug had a reputation as being a very potent steroid useful in attaining mass and for drastically increasing aggression. This drug is the nor-19 derivative of bolasterone and as nandrolone is more potent and more progestational than testosterone, so is the case with mibolerone compared to bolasterone. The addition of the methyl group at C-7 not only increases AR and PR activity but also increases the toxicity of the molecule. Mibolerone is a derivative of nortestosterone (nandrolone); however, it is not metabolized to a less potent dihydronandrolone metabolite due to the shielding effect of the 7-alpha methyl group2.

Like MENT, it is likely that mibolerone is aromatized to form estrogenic metabolites. This steroid is dosed in micrograms (1 milligram is equal to 1000 micrograms) and even so, people still experience significant side effects due to its potent nature. This steroid does not bind to SHBG and even though it is not 5-alpah reduced, it is a very potent androgen on its own and can still exert strong androgenic effects. Mibolerone is well known for causing shedding of hair. It comes as a liquid and a few drugs are taken sublingually under the tongue. Mibolerone is known for causing severe elevations in blood pressure and aggression. It is rumored that a certain professional boxer was using this steroid when the well-known ear-biting episode took place. This steroid is relatively rare, but still pops up from time to time. Most people use it for the strength gains it imparts or for a burst of aggressive energy in strength sports; however, used at a low dose, due to its high AR and PR affinities, this drug can result in pretty substantial mass gains over time. Unfortunately, the liver toxicity of this compound make prolonged dosing an extreme liability.

1. Loughney DA, Schwender CF: A comparison of progestin and androgen receptor binding using the CoMFA technique. J Comput Aided Mol Des. Dec;6(6):569-81, 1992

2. Schanzer W: Metabolism of anabolic androgenic steroids. Clin Chem. Jul;42(7):1001-20, 1996

 

Adapted with permission from Seth Robert’s Anabolic Pharmacology, all rights reserved.

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