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jacked guy military pressMestanolone is the C-17 alpha alkylated version of DHT. This, of course, makes it orally bioavailable. It also adds some progestational activity to the molecule1. Methyl DHT cannot convert to estrogen, but it does bind strongly to SHBG which can displace estrogen into circulation possibly resulting in estrogenic side effects. As stated, DHT is deactivated in skeletal muscle by 3-alpha hydroxysteroid dehydrogenase as will Mestanolone2. However, if large enough doses are taken, it is possible that this enzyme may be overwhelmed and mestanolone would therefore bind to the AR resulting in quite strong anabolism but it has not been determined scientifically if this is possible and what dose would achieve this effect. Some people have an abnormal attraction to DHT and methyl DHT. They reason that since DHT is a stronger androgen that it must be a better anabolic and they refuse to acknowledge that these steroids are deactivated in skeletal muscle. The reason is probably due to the strong effect that DHT has on the psyche of the user. DHT will increase aggression and can cause significant strength gains though nervous stimulation.

 

1. Ojasoo T, Delettre J, Mornon JP, Turpin-VanDycke C, Raynaud JP: Towards the mapping of the progesterone and androgen receptors. J Steroid Biochem. 27(1-3):255-69, 1987

2. Schanzer W: Metabolism of anabolic androgenic steroids. Clin Chem. Jul;42(7):1001-20, 1996

Adapted with permission from Seth Robert’s Anabolic Pharmacology, all rights reserved.

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