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Steroids: Clostebol

Chlorotestosterone is a very simple derivative of testosterone made by attaching a chlorine atom at the 4 position. This slight modification makes for a very different molecule than testosterone. Clostebol has a slightly lower binding affinity for the AR than testosterone and no binding to the PR or GR. The chlorine atom blocks the action of aromatase on this molecule. This means that chlorotestosterone cannot be converted to estrogen and is converted to a less potent DHT derivative1.

Because testosterone is converted to DHT and estrogen to some degree and because DHT and estrogen are inactive in muscle tissue, you lose a good portion of activity when using testosterone. You also lose some of testosterone’s activity due to binding to SHBG. Chlorotestosterone binds much more weakly to SHBG than testosterone does. This makes clostebol a very good choice as an anabolic as can be seen from the anabolic to androgenic ratio.

This steroid was marketed with an acetate ester requiring daily injections. It is surprising that chlorotestosterone is not used more often but this is probably due to the fact that this steroid does not offer instant gratification in the form of “bloat”. A longer ester would make this steroid much more attractive.

The closest thing legally available to this steroid today is Liquid Labs “Te” – a potent prohormone that converts to testosterone once it’s in your body.

1. Schanzer W: Metabolism of anabolic androgenic steroids. Clin Chem. Jul;42(7):1001-20, 1996

Adapted with permission from Seth Robert’s Anabolic Pharmacology, all rights reserved.

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