Agmatine is naturally produced in the body by the breakdown of arginine. Supplementing with agmatine sulfate does many of the same things that arginine should do, but it seems to be much more effective. Agmatine sulfate has many benefits to the bodybuilder or athlete. The benefits if agmatine sulfate include enhanced muscle pumps, better nutrient partitioning (more calories are shuttled towards muscle tissue and less are stored as fat), and increased production of luteinizing hormone and growth hormone.
Boosting Muscle Pumps
Agmatine sulfate appears to boost muscle pumps in a couple different ways. First, agmatine sulfate may improve nutrient partitioning, leading to more muscle glycogen (carbohydrates stored in muscle tissue) stored and consequently more water retained in the muscle. This can lead to a full look to the muscle and increase muscle pumps. Second, agmatine sulfate also appears to increase nitric oxide production by acting as a competitive inhibitor of the enzyme nitric oxide synthase. The nutrient partitioning effects of agmatine may be due to its possible ability to increase the insulin response to carbohydrates, and it may also have something to do with the increased blood flow to the muscle experienced with increased nitric oxide production. Agmatine sulfate may play a role in the hypothalamic control of luteinizing hormone and growth hormone release, leading to increased levels of these hormones.
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As a result of these effects, supplementation with agmatine sulfate may improve athletic performance, increase muscle size, fullness, and vascularity, and may also increase fat loss. It may also have a couple of additional benefits like protection against free radical damage and an antidepressant effect. Arginine worked, but agmatine sulfate appears to be an even better option in terms of physique development and performance.
References1. Li YF, Gong ZH, Cao JB, Wang HL, Luo ZP, & Li J. (2003). Antidepressant-like effect of agmatine and its possible mechanism. European Journal of Pharmacology. 469(1-3), 81-8. 2. Zhu MY, Wang WP, Cai ZW, Regunathan S, & Ordway G. (2008). Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain. The European Journal of Neuroscience. 27(6), 1320-32. 3. Demady DR, Jianmongkol S, Vuletich JL, Bender AT, & Osawa Y. (2001). Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Molecular Pharmacology. 59(1), 24-9. 4. Zarandi M, Serfozo P, Zsigo J, Bokser L, Janaky T, Olsen DB, Bajusz S, & Schally AV. (1992). Potent agonists of growth hormone-releasing hormone. Part I. International Journal of Peptide and Protein Research. 39(3), 211-7. 5. Kalra SP, Pearson E, Sahu A, & Kalra PS. (1995). Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro. Neuroscience Letters. 194(3), 165-8. 6. Arndt MA, Battaglia V, Parisi E, Lortie MJ, Isome M, Baskerville C, Pizzo DP, Ientile R, Colombatto S, Toninello A, & Satriano J. (2009). The arginine metabolite agmatine protects mitochondrial function and confers resistance to cellular apoptosis. American Journal of Physiology. Cell Physiology. 296(6), C1411-9.
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