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muscled guy posing5-Androstenediol, commonly known as 5 AD, may appear under the nomenclature 5-androsten-3b, 17b-diol. 5 AD occurs naturally in the body as a metabolite of DHEA. 5 AD was released early on in the prohormone era, not long after the first prohormone androstenedione. It is very similar in structure to the steroid methandriol, but 5 AD lacks the ester chains at either end of the molecule and the C-17 methyl group that methandriol has.

With an anabolic to androgenic ratio of 10/20, 5 AD is not very anabolically active. It actually has an androgen receptor binding affinity that is even lower than estradiol. 5 AD also has a moderate rate of conversion to estrogen and it may even directly stimulate the estrogen receptor. Users of 5 AD experienced little in the way of actual gains but estrogen related side effects such as gynecomastia were common. Due to its lack of effectiveness and estrogenic side effects, 5 AD lost popularity rapidly. At this point all manufacturers of 5 AD products have discontinued sales of this prohormone.

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 1. Roberts, S (2009). Anabolic Pharmacology.

 2. Umstot ES. (1988). Additional binding sites for delta 5-androstenediol and estradiol in serum. Annals of the New York Academy of Sciences. 538, 204-10.

 3. D’Astous M, Morissette M, & Di Paolo T. (2004). Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER alpha agonist. Neuropharmacology. 47(8), 1180-8.

 4. Broeder CE. (2003). Oral andro-related prohormone supplementation: do the potential risks outweigh the benefits? Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée. 28(1), 102-16.

 5. Andersson S, Geissler WM, Patel S, & Wu L. (1995). The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases. The Journal of Steroid Biochemistry and Molecular Biology. 53(1-6), 37-9.


[author] [author_image timthumb=’on’][/author_image] [author_info]ABOUT THE AUTHOR: Cassie is a chemistry major and national level bodybuilder. Questions or comments?



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