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muscled man lifting4-DHEA has many health benefits over standard 5-DHEA since it may not have intrinsic estrogenic activity. This means that men and women, who are already overloaded with environmental estrogens from things like BPA and pesticides, can enjoy the health benefits of DHEA without adding to their estrogen load.

4-DHEA may reduce muscle loss as we age without the negative effects of standard DHEA therapy.  This means that people who use DHEA will want to talk to their naturopath or doctor about the benefits of these new forms of DHEA such as 4-DHEA and others.


4-DHEA may appear under the nomenclature 4-androstene-3b-ol, 17-one. 4-DHEA does not have much anabolic activity on its own, but it converts to testosterone in a two-step process involving the enzymes 3bHSD and 17bHSD. 4-DHEA first converts to androstenediol and androstenedione and then to testosterone. 4-DHEA is best used during mass gaining phases rather then during dieting phases, as it is considered to be a “wet” prohormone that is associated with mass gains that come with some temporary bloating.

The estrogenic side effects of 4-DHEA have been significantly reduced in comparison to DHEA. 4-DHEA can convert to estrogen but it cannot act directly in the estrogen receptor like DHEA, so any estrogenic side effects experienced with 4-DHEA use are a result of increased estrogen levels only. As with most prohormones, estrogenic side effects such as gynecomastia are a possibility with 4-DHEA. 4-DHEA is not methylated, so liver stress is not a concern.

4-DHEA would normally need to be taken in very high doses to see an anabolic effect, but taking it sublingually (where the compound is absorbed through the tissue under the tongue) can greatly improve absorption. 4-DHEA is currently completely legal and available over the counter, and should produce results similar to 4-androstenediol which was banned in the Anabolic Steroid Control Act of 2004.

To view 100% legal and effective prohormones including 4-DHEA (4-androstene-3b-ol, 17-one), click here.



Roberts, S (2009). Anabolic Pharmacology.


[author] [author_image timthumb=’on’][/author_image] [author_info]ABOUT THE AUTHOR: Cassie is a chemistry major and national level bodybuilder. Questions or comments?

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